3t7v: Difference between revisions

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[[Image:3t7v.png|left|200px]]


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==Crystal structure of methylornithine synthase (PylB)==
The line below this paragraph, containing "STRUCTURE_3t7v", creates the "Structure Box" on the page.
<StructureSection load='3t7v' size='340' side='right'caption='[[3t7v]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3t7v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_barkeri_str._Fusaro Methanosarcina barkeri str. Fusaro]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T7V FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MD0:5-AMINO-D-ISOLEUCINE'>MD0</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
{{STRUCTURE_3t7v|  PDB=3t7v  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t7v OCA], [https://pdbe.org/3t7v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t7v RCSB], [https://www.ebi.ac.uk/pdbsum/3t7v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t7v ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PYLB_METBF PYLB_METBF] Catalyzes the isomerization of L-lysine to (2R,3R)-3-methylornithine via a radical-based mechanism, a step in the biosynthesis pathway of pyrrolysine.<ref>PMID:21455182</ref> <ref>PMID:22095926</ref>
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== Publication Abstract from PubMed ==
Made by the barrel load: The biosynthetic pathway of the recently discovered 22nd amino acid, pyrrolysine, starts with an isomerization of lysine to methylornithine, catalyzed by PylB. The X-ray crystal structure of PylB is determined and shows it has a TIM barrel fold. The sealed central cavity contains a [4Fe-4S] cluster, S-adenosylmethionine (SAM), and methylornithine, whose 2R,3R configuration could be confirmed. The data suggest a fragmentation-recombination mechanism via a glycyl radical intermediate.


===Crystal structure of methylornithine synthase (PylB)===
Crystal Structure of Methylornithine Synthase (PylB): Insights into the Pyrrolysine Biosynthesis.,Quitterer F, List A, Eisenreich W, Bacher A, Groll M Angew Chem Int Ed Engl. 2011 Nov 16. doi: 10.1002/anie.201106765. PMID:22095926<ref>PMID:22095926</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3t7v" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 22095926 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_22095926}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[3t7v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_barkeri Methanosarcina barkeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7V OCA].
[[Category: Methanosarcina barkeri str. Fusaro]]
 
[[Category: Bacher A]]
==Reference==
[[Category: Eisenreich W]]
<ref group="xtra">PMID:022095926</ref><references group="xtra"/>
[[Category: Groll M]]
[[Category: Biotin synthase]]
[[Category: List A]]
[[Category: Methanosarcina barkeri]]
[[Category: Quitterer F]]
[[Category: Bacher, A.]]
[[Category: Eisenreich, W.]]
[[Category: Groll, M.]]
[[Category: List, A.]]
[[Category: Quitterer, F.]]
[[Category: 3-methylornithine]]
[[Category: Lysine]]
[[Category: Mutase]]
[[Category: Sam]]
[[Category: Tim-barrel fold]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/3t7v"