MDM4: Difference between revisions

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New page: {{STRUCTURE_3dab| PDB=3dab | SIZE=400| SCENE=1 |right|CAPTION=Human MDM4 complex with p53 transactivation domain , 3dab }} '''MDM4''' is a 490 amino acid protein containing a RING f...
 
Michal Harel (talk | contribs)
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{{STRUCTURE_3dab|  PDB=3dab | SIZE=400| SCENE=1 |right|CAPTION=Human MDM4 complex with p53 transactivation domain , [[3dab]] }}
<StructureSection load='3dab' size='350' side='right' caption='Human MDM4 p53-binding domain (grey) complex with p53 peptide (green) (PDB entry [[3dab]])' scene=''>
== Function ==
'''MDM4''' or '''MDMX''' is a 490 amino acid protein containing a RING finger domain (residues 300-339) and a nuclear localization signal. MDM4 interacts with protein MDM2<ref>PMID:12101245</ref>.  Both of these proteins show structure similarity and contain a p53-binding domain (or SWIB domain) in their N terminal (residues 23-111).


'''MDM4''' is a 490 amino acid protein containing a RING finger domain and a nuclear localization signal. MDM4 interacts with protein MDM2.  Both of these proteins show structure similarity and contain a p53-binding domain in their N terminal.
== Relevance ==
MDM4 which is a negative regulator of p53 is upregulated in human melanomas and thus is a key therapeutic target<ref>PMID:22820643</ref>.  
</StructureSection>
== 3D Structures of MDM4 ==


{{TOC limit|limit=2}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}


== 3D Structures of MDM4 ==
MDM4 domains: p53-binding 24-111; zinc finger RNBP 290-335; zinc finger-RING 428-490
 
[[2cr8]] – hMDM4 ZF-RNBP domain – NMR<br />
[[3dab]], [[2mwy]], [[7el4]] – hMDM4 p53-binding domain + p53 transactivation domain<br />
[[3dac]] – hMDM4 p53-binding domain (mutant) + p53 transactivation domain<br />
[[2n06]], [[2n0u]], [[2n0w]], [[2n14]] – hMDM4 p53-binding domain + p53 transactivation domain – NMR<br />
[[3fdo]], [[3jzo]], [[3jzp]], [[3jzq]], [[4rxz]], [[5uml]], [[7kjn]] – hMDM4  p53-binding domain + peptide inhibitor<br />
[[5vk1]] – hMDM4 p53-binding domain + stapled peptide<br />
[[3lbj]], [[3u15]], [[8ia5]] – hMDM4 p53-binding domain + inhibitor<br />
[[3fe7]], [[3fea]], [[3eqy]] - hMDM4 p53-binding domain (mutant) + peptide<br />
[[6q9q]], [[6q9s]], [[6q9u]], [[6q9w]], [[6q9y]] – hMDM4 p53-binding domain (mutant)+ inhibitor<br />
[[7c3q]], [[7c3y]], [[7c44]] – hMDM4 p53-binding domain + nutlin<br />
[[2vyr]] – hMDM4 p53-binding domain + antibody<br />
[[2vje]], [[2vjf]] – hMDM4 ZF-RING domain + hMDM2 residues 383-446<br />
[[5mnj]] – hMDM4 ZF-RING domain + hMDM2 ZF-RING domain + polyubiquitin + ubiquitin-conjugating enzyme E2<br />
[[7mla]] – hMDM4 ZF-RING domain + cyclotide - NMR<br />
[[2z5s]] - zMDM4 p53-binding domain + p53 transactivation domain – zebrafish<br />
[[2z5t]] - zMDM4 p53-binding domain (mutant) + p53 transactivation domain <br />
[[8gjs]] - zMDM4 p53-binding domain + stapled peptide <br />
[[4n5t]], [[6v4e]], [[6v4f]], [[6v4g]], [[6v4h]] - zMDM4 p53-binding domain (mutant) + stapled peptide <br />


2cr8 – hMDM4 ZF-RNBP domain – NMR
== References ==
3dab – hMDM4 + p53 transactivation domain
<references/>
3fdo, 3jzo, 3jzp, 3jzq, 3jzr, 3jzs – hMDM4  p53-binding domain + peptide
[[Category:Topic Page]]
3lbj - hMDM4  p53-binding domain + inhibitor
3dac – hMDM4 (mutant) + p53 transactivation domain
2vyr – hMDM4 N terminal + antibody
3fe7, 3fea, 3eqy - hMDM4 N terminal (mutant) + peptide
2vje, 2vjf – hMDM2 residues 383-446 + hMDM4 residues 428-490

Latest revision as of 08:01, 16 December 2025

Human MDM4 p53-binding domain (grey) complex with p53 peptide (green) (PDB entry 3dab)

Drag the structure with the mouse to rotate

3D Structures of MDM4

Updated on 16-December-2025

MDM4 domains: p53-binding 24-111; zinc finger RNBP 290-335; zinc finger-RING 428-490

2cr8 – hMDM4 ZF-RNBP domain – NMR
3dab, 2mwy, 7el4 – hMDM4 p53-binding domain + p53 transactivation domain
3dac – hMDM4 p53-binding domain (mutant) + p53 transactivation domain
2n06, 2n0u, 2n0w, 2n14 – hMDM4 p53-binding domain + p53 transactivation domain – NMR
3fdo, 3jzo, 3jzp, 3jzq, 4rxz, 5uml, 7kjn – hMDM4 p53-binding domain + peptide inhibitor
5vk1 – hMDM4 p53-binding domain + stapled peptide
3lbj, 3u15, 8ia5 – hMDM4 p53-binding domain + inhibitor
3fe7, 3fea, 3eqy - hMDM4 p53-binding domain (mutant) + peptide
6q9q, 6q9s, 6q9u, 6q9w, 6q9y – hMDM4 p53-binding domain (mutant)+ inhibitor
7c3q, 7c3y, 7c44 – hMDM4 p53-binding domain + nutlin
2vyr – hMDM4 p53-binding domain + antibody
2vje, 2vjf – hMDM4 ZF-RING domain + hMDM2 residues 383-446
5mnj – hMDM4 ZF-RING domain + hMDM2 ZF-RING domain + polyubiquitin + ubiquitin-conjugating enzyme E2
7mla – hMDM4 ZF-RING domain + cyclotide - NMR
2z5s - zMDM4 p53-binding domain + p53 transactivation domain – zebrafish
2z5t - zMDM4 p53-binding domain (mutant) + p53 transactivation domain
8gjs - zMDM4 p53-binding domain + stapled peptide
4n5t, 6v4e, 6v4f, 6v4g, 6v4h - zMDM4 p53-binding domain (mutant) + stapled peptide

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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