4dbs: Difference between revisions
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New page: '''Unreleased structure''' The entry 4dbs is ON HOLD Authors: Chen, M., Christianson, D.W., Winkler, J.D., Penning, T.M. Description: Crystal structure of human 17beta-hydroxysteroid d... |
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==Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3'-[(4-nitronaphthalen-1-yl)amino]benzoic acid== | |||
<StructureSection load='4dbs' size='340' side='right'caption='[[4dbs]], [[Resolution|resolution]] 1.85Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4dbs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DBS FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.852Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0HV:3-[(4-NITRONAPHTHALEN-1-YL)AMINO]BENZOIC+ACID'>0HV</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dbs OCA], [https://pdbe.org/4dbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dbs RCSB], [https://www.ebi.ac.uk/pdbsum/4dbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dbs ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | |||
==See Also== | |||
*[[Prostaglandin F synthase 3D structures|Prostaglandin F synthase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen M]] | |||
[[Category: Christianson DW]] | |||
[[Category: Penning TM]] | |||
[[Category: Winkler JD]] | |||
Latest revision as of 14:30, 14 March 2024
Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3'-[(4-nitronaphthalen-1-yl)amino]benzoic acid
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