Response regulator: Difference between revisions

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{{STRUCTURE_1zg1|  PDB=1zg1  | SIZE=400| SCENE= |right|CAPTION=Se-Met ''E. coli'' response regulator NarL complex with DNA and sulfate, [[1zg1]] }}
<StructureSection load='1kgs' size='350' side='right' scene='' caption='Se-Met DNA-binding response regulator D complex with thiocyanate, [[1kgs]]'>
 
'''Response regulators''' (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments.
'''Response regulators''' (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments.
Two-component RR is a complex of histidine kinase (sensor protein SP) and RR.  The RR act as phosphorylation-activated switches.  Most RR consist of N terminal shich is the signal receiving domain and C terminal which is the DNA-binding domain.  RR CheY is a chemotaxis  response regulator in bacteria.  RR Spo0 is the sporulation response regulator.  Details on response regulator PleD see [[PleD activation]], [[PleD allosteric product inhibition]], [[PleD catalysis]].  For details on PhoP see [[PhoP Regulatory Domain]] and [[PhoP-PhoQ]].
Two-component RR is a complex of histidine kinase (sensor protein SP) and RR.  The RR act as phosphorylation-activated switches.  Most RR consist of N terminal which is the signal receiving domain and C terminal which is the DNA-binding domain (DBD).


*'''RR CheY''' is a chemotaxis  response regulator in bacteria see [[Chemotaxis protein]].<ref>PMID:14563873</ref>. <br />
*'''RR Spo0''' is the sporulation response regulator<ref>PMID:12829280</ref>. <br />
*'''RR PleD''' is required in loss of motility<ref>PMID:7592388</ref>. For details see [[PleD activation]], [[PleD allosteric product inhibition]], [[PleD catalysis]] and [[Response regulator PLED in complex with C-di-GMP]]<br />
*'''RR PhoP''' is important for survival under conditions of macrophage-induced stress<ref>PMID:21634789</ref>. For details see [[PhoP Regulatory Domain]] and [[PhoP-PhoQ]]<br />
*'''Photosynthetic apparatus RR''' in ''Rhodobacter sphaeroides'' is involved in the transduction of signals which monitor oxygen levels.  <ref>PMID:8955382</ref>. For details see [[PrrA in Rhodobacter sphaeroides]] <br />
*'''RR WspR''' couples the chemosensory Wsp pathway to the overproduction of acetylated cellulase <ref>PMID:17379708</ref>. For details see [[WspR]].<br />
*'''Redox RR''' is DNA-sequence specific.  It controls transcription as a result of its phosphorylation by a redox sensor<ref>PMID:8405457</ref>. <br />


{{TOC limit|limit=2}}
For '''iron response regulator Irr''' see [[Irr]].


== 3D Structures of response regulator ==
== 3D Structures of response regulator ==
[[Response regulator 3D structure]]


''Updated December 2011''
</StructureSection>
 
===Nitrate/nitrite RR===
 
[[1rnl]], [[1a04]] – EcNarL – ''Escherichia coli''<br/ >
[[1je8]], [[1zg1]], [[1zg5]] – EcNarL DNA-binding domain + DNA
 
===Sporulation RR===
 
[[1srr]] – BsSpo0F (mutant) – ''Bacillus subtilis''<br/ >
[[1nat]] - BsSpo0F<br/ >
[[3q15]] - BsSpo0F + RR aspartate phosphatase<br/ >
[[1ixm]] - BsSpo0B<br/ >
[[1fc3]] – Spo0A trans-activation domain – ''Geobacillus stearothermophilus''
 
===DNA-binding RR===
 
[[1kgs]] – TmDrrD – ''Thermotoga maritima''<br/ >
[[3nnn]] – TmDrrD receiver domain + BeF3<BR/ >
[[1p2f]] – TmDrrB<br/ >
[[3nns]] - TmDrrB receiver domain + BeF3<BR/ >
[[1nxo]], [[1nxp]], [[1nxs]], [[1nxt]], [[1nxv]], [[1nxw]], [[1nxx]] – SpMicArec receiver domain – ''Streptococcus pneumonia''<br/ >
[[2gwr]] - MtMtrA – ''Mycobacterium tuberculosis''<br/ >
[[2hwv]] – VicR C terminal – ''Enterococcus faecalis''<br/ >
[[2qsj]] – LuxR – ''Silicibbacter pomeroyi''<br/ >
[[3cnb]], 3eqz]] – MerR receiver domain – ''Colwellia psychrerythraea''<br/ >
[[2rnj]] – SaVraR DNA-binding domain – ''Staphylococcus aureus'' – NMR<br/ >
[[2zxj]] - SaWalR DNA-binding domain<br/ >
[[3q9s]] – DrRR receiver domain – ''Deinococcus radiodurans''<br/ >
[[3q9v]] - DrRR C terminal
 
 
===Cyanobacterial phytochrome RR===
 
[[1i3c]] – SyRcp1 – ''Synechocystis''<br/ >
[[1jlk]] – SyRcp1 + Mn<br/ >
[[1k66]] – ToRcpB – ''Tolypothrix''<br/ >
[[1k68]] – ToRcpB
 
===Phosphatase synthesis RR===
 
[[1mvo]] – BsPhoP receiver domain<br/ >
[[2jb9]], [[2jba]] – EcPhoB (mutant) <br/ >
[[2pmu]] – MtPhoP DNA-binding domain
 
===Polar differentiation RR===
 
[[1m5t]], [[1m5u]] – CvDivK – ''Caulobacter vibrioides''<br/ >
[[1mav]], [[1mb0]], [[1mb3]] – CvDivK + cation
 
===Photosynthetic apparatus RR===
 
[[1umq]] – PrrA DNA-binding domain – ''Rhodobacter sphaeroides'' – NMR<br/ >
[[1ys6]] – MtPrrA <br/ >
[[1ys7]] – MtPrrA + Mg
 
===Redox RR===
 
[[1xhe]] – EcArcA receiver domain <br/ >
[[1xhf]] – EcArcA receiver domain + BeF3<BR/ >
 
===Social motility RR===
 
[[2gkg]], [[2i6f]] – MxFrzS receiver domain – ''Myxococcus xanthus'' <br/ >
[[2nt3]], [[2nt4]] - MxFrzS receiver domain (mutant)
 
===Stalked-cell differentiation RR===
 
[[2v0n]] – CvPleD + GMP + GTP<br/ >
[[2wb4]], 1w25]] - CvPleD + GMP
 
===Hypoxic RR===
 
[[3c3w]] – MtDosR<br/ >
[[3c57]] – MtDosR C terminal
 
===Transcriptional RR===
 
[[2zwm]] – BsYycF receiver domain<br/ >
[[3ulq]] – BsComA DNA-binding domain + RR aspartate phosphatase
 
===Stress RR===
 
[[3n0r]] – CVPhyR
 
===CheY-like RR===
 
[[3snk]] – RR – ''Mesorhizobium loti''<br/ >
[[3cg4]], [[3crn]] - RR receiver domain – ''Methanospirillum hungatei''<br/ >
[[3i42]] – RR receiver domain – ''Methylobacter flagellates''
 
===Unspecified RR receiver domain===
 
[[2a9o]], [[2a9p]], [[2a9q]] – SpRR + Mn + BeF3<BR/ >
[[2a9r]] – SpRR + phosphate + Mg<br/ >
[[2pln]] – HP1043 – ''Helicobacter pylori''<br/ >
[[2qr3]] – RR – ''Bacteroides fragilis''<br/ >
[[2qxy]] – TmRR <br/ >
[[2qzj]] – RR – ''Clostridium difficile''<br/ >
[[3kht]] – RR – ''Hahella chejuensis''<br/ >
[[3c3m]] – RR – ''Methanoculleus marisnigri''<br/ >
[[3cz5]] – RR – ''Aurantimonas''<br/ >
[[3heb]] - RR – ''Rhodospirillum rubrum''<br/ >
[[3lte]] – RR – ''Bermanella marisrubri''<br/ >
[[3jte]], [[3lua]] – RR – ''Clostridium thermocellum''
 
===Unspecified RR===
 
[[1yio]], [[1zn2]] – StyR – ''Pseudomonas fluorescens''<br/ >
[[3a0u]], [[3a10]] – TmTrrA + Mg + BeF3<BR/ >
[[2qvg]] – RR – ''Legionella pneumophila''<br/ >
[[3gl9]] - TmRR<br/ >
[[2zay]] – RR – ''Desulfuromonas acetoxidans''<br/ >
[[2rdm]] – RR (mutant) – ''Sinorhizobium medicae''<br/ >
[[3bre]] – PaRR – ''Pseudomonas aeruginosa''<br/ >
[[3hdv]] – RR – ''Pseudomonas putida''<br/ >
[[3i5a]] – PsWspR – ''Pseudomonas syringae''<br/ >
[[3ilh]] – RR – ''Cytophaga hutchinsonii''<br/ >
[[3i5b]] – PaWspR GGDEF domain<br/ >
[[3i5c]] – PaWspR GGDEF domain/GCN4 leucine zipper<br/ >
[[3ljx]] – McMmoQ – ''Methylococcus capsulatus''<br/ >
[[3p3q]] – McMmoQ (mutant) <br/ >
[[3lsg]] – RR C terminal – ''Fusobacterium nucleatum''<br/ >
[[3nhm]] – MxRR<br/ >
[[3m6m]] – XcRpfC REC domain + enoyl-CoA hydratase – ''Xanthomonas campestris''<br/ >
[[3qyy]] – XcRR GGDEF domain + GMP<br/ >
[[3p01]] – RR residues 134-315 – ''Nostoc''<br/ >
[[3rqi]] – RR + phosphate + Ca + citrate – ''Burkholderia pseudomallei''<br/ >
[[3kto]] – RR - ''Pseudoalteromonas atlantica''
 
===RR complex with histidine kinase===
 
[[3dge]], 3dgf]] – TmRR + sensor protein<br/ >
[[3a0r]] – TmTrrA (mutant) + sensor protein
 
 
 
 
 
 


== References ==
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 12:17, 9 December 2019

Se-Met DNA-binding response regulator D complex with thiocyanate, 1kgs

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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