3vqg: Difference between revisions
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New page: '''Unreleased structure''' The entry 3vqg is ON HOLD Authors: Akiyoshi, Y., Hamada, D., Goda, N., Tenno, T., Narita, H., Nakagawa, A., Furuse, M., Suzuki, M., Hiroaki, H. Description: ... |
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==Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein== | |||
<StructureSection load='3vqg' size='340' side='right'caption='[[3vqg]], [[Resolution|resolution]] 1.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3vqg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VQG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vqg OCA], [https://pdbe.org/3vqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vqg RCSB], [https://www.ebi.ac.uk/pdbsum/3vqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vqg ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/LNX1_MOUSE LNX1_MOUSE] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. | |||
==See Also== | |||
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Akiyoshi Y]] | |||
[[Category: Furuse M]] | |||
[[Category: Goda N]] | |||
[[Category: Hamada D]] | |||
[[Category: Hiroaki H]] | |||
[[Category: Nakagawa A]] | |||
[[Category: Narita H]] | |||
[[Category: Suzuki M]] | |||
[[Category: Tenno T]] | |||
Latest revision as of 12:33, 8 November 2023
Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein
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