3r43: Difference between revisions

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[[Image:3r43.jpg|left|200px]]


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==AKR1C3 complexed with mefenamic acid==
The line below this paragraph, containing "STRUCTURE_3r43", creates the "Structure Box" on the page.
<StructureSection load='3r43' size='340' side='right'caption='[[3r43]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3r43]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R43 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ID8:2-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC+ACID'>ID8</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
{{STRUCTURE_3r43|  PDB=3r43  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r43 OCA], [https://pdbe.org/3r43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r43 RCSB], [https://www.ebi.ac.uk/pdbsum/3r43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r43 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.


===AKR1C3 complexed with mefenamic acid===
==See Also==
 
*[[Prostaglandin F synthase 3D structures|Prostaglandin F synthase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
[[3r43]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R43 OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Squire, C J.]]
[[Category: Large Structures]]
[[Category: Teague, R M.]]
[[Category: Squire CJ]]
[[Category: Yosaatmadja, L.]]
[[Category: Teague RM]]
[[Category: Aldo-keto reductase]]
[[Category: Yosaatmadja L]]
[[Category: Nitro reductase]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Tim barrel]]

Latest revision as of 12:09, 14 March 2024

AKR1C3 complexed with mefenamic acid

3r43, resolution 2.00Å

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