Cardiotoxin: Difference between revisions

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[[Image:2cdx.png|left|200px|thumb|NMR Structure of cardiotoxin CTX I from ''Naja naja atra'' [[2cdx]]]]
<StructureSection load='2cdx' size='350' side='right' scene='42/425149/Cv/2' caption='Cardiotoxin CTX I [[2cdx]]'>
{{STRUCTURE_2cdx|  PDB=2cdx  | SIZE=400| SCENE=Cardiotoxin/Cv/1 |right|CAPTION=Cardiotoxin CTX I [[2cdx]] }}


[[Cardiotoxin]] (CTX) is a snake toxin from the Taiwan cobra ''Naja naja''.  The cardiotoxin from the Malayan krait is called '''bucain'''. The images at the left and at the right correspond to one representative CTX, ''i.e.'' the NMR structure of cardiotoxin CTX I from ''Naja naja atra'' ([[2cdx]]).  For toxins in Proteopedia see [[Toxins]].


{{TOC limit|limit=2}}
== Function ==
 
'''Cardiotoxin''' or '''cytotoxin''' (CTX) is a snake toxin from the Taiwan cobra ''Naja naja''.  The cardiotoxin from the Malayan krait is called '''bucain'''.  CTX perturb the membrane structure of cells by interaction with lipids. <ref>PMID:3472200</ref> For toxins in Proteopedia see [[Toxins]].<br />
 
== Relevance ==
 
'''Cardiotoxin I''' causes necrosis of skeletal muscle cells.
'''Cardiotoxin III''' induces apoptosis in K562 cells.


== 3D Structures of Cardiotoxin ==
== 3D Structures of Cardiotoxin ==
[[Cardiotoxin 3D structures]]


</StructureSection>


[[2cdx]] - NaCTX I – NMR – ''Naja atra''<br />
== References ==
[[1cre]], [[1crf]] - NaCTX II – NMR<br />
<references />
[[2ccx]] – NmCTX II – ''Naja mossambica'' – NMR<br />
[[1cdt]] – NmCTX II<br />
[[1ffj]], [[1cb9]], [[1ccq]] – CTX II – ''Naja oxiana'' – NMR<br />
[[1i02]], [[2crs]], [[2crt]] - NaCTX III – NMR<br />
[[1xt3]], [[1h0j]] – NaCTX III<br />
[[1kbs]], [[1kbt]] - NaCTX IV – NMR<br />
[[1chv]], [[1cvo]] – NaCTX V – NMR<br />
[[1kxi]] - NaCTX V<br />
[[1ug4]] – CTX VI<br />
[[1cxn]], [[1cxo]], [[1tgx]] – γ-CTX – ''Naja nigricollis'' - NMR<br />
[[2h8u]] – Bucain<br />
[[2bhi]] – CTX III+sulfogalactoceramide<br />


[[Category:Topic Page]]
[[Category:Topic Page]]
Retrieved from "https://proteopedia.org/Cardiotoxin"