4dk7: Difference between revisions

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[[Image:4dk7.png|left|200px]]


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==Crystal structure of LXR ligand binding domain in complex with full agonist 1==
The line below this paragraph, containing "STRUCTURE_4dk7", creates the "Structure Box" on the page.
<StructureSection load='4dk7' size='340' side='right'caption='[[4dk7]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[4dk7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DK7 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0KS:N-[4-(1,1,1,3,3,3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL)PHENYL]-N-METHYLBENZENESULFONAMIDE'>0KS</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
{{STRUCTURE_4dk7|  PDB=4dk7  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dk7 OCA], [https://pdbe.org/4dk7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dk7 RCSB], [https://www.ebi.ac.uk/pdbsum/4dk7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dk7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Structural modification of a series of dual LXRalpha/beta agonists led to the identification of a new class of LXRbeta partial agonists. An X-ray co-crystal structure shows that a representative member of this series, pyrrole 5, binds to LXRbeta with a reversed orientation compared to 1.


===Crystal structure of LXR ligand binding domain in complex with full agonist 1===
Discovery of a new binding mode for a series of liver X receptor agonists.,Kopecky DJ, Jiao XY, Fisher B, McKendry S, Labelle M, Piper DE, Coward P, Shiau AK, Escaron P, Danao J, Chai A, Jaen J, Kayser F Bioorg Med Chem Lett. 2012 Apr 1;22(7):2407-10. Epub 2012 Feb 20. PMID:22406115<ref>PMID:22406115</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4dk7" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_22406115}}, adds the Publication Abstract to the page
*[[Liver X receptor|Liver X receptor]]
(as it appears on PubMed at http://www.pubmed.gov), where 22406115 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_22406115}}
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</StructureSection>
==About this Structure==
[[4dk7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DK7 OCA].
 
==Reference==
<ref group="xtra">PMID:022406115</ref><references group="xtra"/>
[[Category: Histone acetyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Piper, D E.]]
[[Category: Large Structures]]
[[Category: Xu, H.]]
[[Category: Piper DE]]
[[Category: Ligand binding domain]]
[[Category: Xu H]]
[[Category: Nuclear hormone receptor]]
[[Category: Transcription-peptide-agonist complex]]

Latest revision as of 09:55, 30 October 2024

Crystal structure of LXR ligand binding domain in complex with full agonist 1

4dk7, resolution 2.45Å

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