4fbn: Difference between revisions
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New page: '''Unreleased structure''' The entry 4fbn is ON HOLD Authors: Cole, A.R., Mas-Droux, C.P., Bunney, T.D., Katan, M. Description: Insights into structural integration of the PLCgamma reg... |
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==Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains== | |||
<StructureSection load='4fbn' size='340' side='right'caption='[[4fbn]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4fbn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FBN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fbn OCA], [https://pdbe.org/4fbn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fbn RCSB], [https://www.ebi.ac.uk/pdbsum/4fbn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fbn ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PLCG1_HUMAN PLCG1_HUMAN] Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.<ref>PMID:17229814</ref> | |||
==See Also== | |||
*[[Phospholipase C|Phospholipase C]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bunney TD]] | |||
[[Category: Cole AR]] | |||
[[Category: Katan M]] | |||
[[Category: Mas-Droux CP]] | |||
Latest revision as of 11:13, 1 March 2024
Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains
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