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[[Image:3ozf.png|left|200px]]


{{STRUCTURE_3ozf| PDB=3ozf | SCENE= }}
==Crystal Structure of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase in complex with hypoxanthine==
<StructureSection load='3ozf' size='340' side='right'caption='[[3ozf]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ozf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_FCR-3/Gambia Plasmodium falciparum FCR-3/Gambia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OZF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.944&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HPA:HYPOXANTHINE'>HPA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ozf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ozf OCA], [https://pdbe.org/3ozf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ozf RCSB], [https://www.ebi.ac.uk/pdbsum/3ozf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ozf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HGXR_PLAFG HGXR_PLAFG] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Works with guanine, hypoxanthine and xanthine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.


===Crystal Structure of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase in complex with hypoxanthine===
==See Also==
 
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
{{ABSTRACT_PUBMED_22726686}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[3ozf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Eukaryota Eukaryota]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OZF OCA].
[[Category: Plasmodium falciparum FCR-3/Gambia]]
 
[[Category: Almo SC]]
==Reference==
[[Category: Hazleton KZ]]
<ref group="xtra">PMID:022726686</ref><references group="xtra"/>
[[Category: Ho M]]
[[Category: Eukaryota]]
[[Category: Schramm VL]]
[[Category: Almo, S C.]]
[[Category: Hazleton, K Z.]]
[[Category: Ho, M.]]
[[Category: Schramm, V L.]]
[[Category: Hypoxanthine]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/3ozf"