4fbq: Difference between revisions

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[[Image:4fbq.png|left|200px]]


{{STRUCTURE_4fbq|  PDB=4fbq  |  SCENE=  }}
==Crystal structure of a covalently fused Nbs1-Mre11 complex with two manganese ions per active site==
 
<StructureSection load='4fbq' size='340' side='right'caption='[[4fbq]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
===Crystal structure of a covalently fused Nbs1-Mre11 complex with two manganese ions per active site===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4fbq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FBQ FirstGlance]. <br>
{{ABSTRACT_PUBMED_22705791}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fbq OCA], [https://pdbe.org/4fbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fbq RCSB], [https://www.ebi.ac.uk/pdbsum/4fbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fbq ProSAT]</span></td></tr>
[[4fbq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBQ OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/RAD32_SCHPO RAD32_SCHPO] Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51.[https://www.uniprot.org/uniprot/NBS1_SCHPO NBS1_SCHPO] Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure.<ref>PMID:12944481</ref> <ref>PMID:12944482</ref>
<ref group="xtra">PMID:022705791</ref><references group="xtra"/>
== References ==
[[Category: Schizosaccharomyces pombe]]
<references/>
[[Category: Hopfner, K P.]]
__TOC__
[[Category: Lammens, K.]]
</StructureSection>
[[Category: Schiller, C B.]]
[[Category: Large Structures]]
[[Category: Dna double-strand break repair]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Hydrolase]]
[[Category: Hopfner KP]]
[[Category: Nuclease]]
[[Category: Lammens K]]
[[Category: Protein binding]]
[[Category: Schiller CB]]

Latest revision as of 11:13, 1 March 2024

Crystal structure of a covalently fused Nbs1-Mre11 complex with two manganese ions per active site

4fbq, resolution 2.50Å

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