3c92: Difference between revisions
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==Thermoplasma acidophilum 20S proteasome with a closed gate== | |||
<SX load='3c92' size='340' side='right' viewer='molstar' caption='[[3c92]], [[Resolution|resolution]] 6.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3c92]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C92 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.8Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c92 OCA], [https://pdbe.org/3c92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c92 RCSB], [https://www.ebi.ac.uk/pdbsum/3c92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c92 ProSAT]</span></td></tr> | |||
== | </table> | ||
[[3c92]] is a 28 chain structure | == Function == | ||
[https://www.uniprot.org/uniprot/PSA_THEAC PSA_THEAC] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The T.acidophilum proteasome is able to cleave oligopeptides after Tyr, Leu, Phe, and to a lesser extent after Glu and Arg. Thus, displays chymotrypsin-like activity and low level of caspase-like and trypsin-like activities.<ref>PMID:8999862</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c9/3c92_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c92 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Proteasome|Proteasome]] | *[[Proteasome 3D structures|Proteasome 3D structures]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
[[Category: | </SX> | ||
[[Category: Large Structures]] | |||
[[Category: Thermoplasma acidophilum]] | [[Category: Thermoplasma acidophilum]] | ||
[[Category: Chang | [[Category: Chang SC]] | ||
[[Category: Cheng | [[Category: Cheng Y]] | ||
[[Category: Goldberg | [[Category: Goldberg AL]] | ||
[[Category: Rabl | [[Category: Rabl J]] | ||
[[Category: Smith | [[Category: Smith DM]] | ||
[[Category: Yu | [[Category: Yu Y]] | ||
Latest revision as of 09:33, 21 February 2024
Thermoplasma acidophilum 20S proteasome with a closed gate
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