Proteasome 3D structures
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3D Structures of Proteasome
Updated on 29-July-2026
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- Proteasome 13S core
- 8tm4, 8tm5 – h13S – human - Cryo EM
- 5dsv, 7e55 – h13S subunit alpha type 3
- 9d4u – y13S 7 alpha + 3 beta + UMP1 – yeast - Cryo EM
- 7lsx, 9rl3 – y13S 7 alpha + 3 beta + UMP1 + chaperone 1,2 - Cryo EM
- 9rla, 9rlt – y13S 7 alpha + 1 beta + UMP1 + chaperone 1,2 - Cryo EM
- 9rm0, 9rm1 – y13S 7 alpha + 2 beta + UMP1 + chaperone 1,2 - Cryo EM
- 9d0t – y13S core 7 alpha + 3 beta + Blm10 – Cryo EM
- 9d4c – y13S core 7 alpha+ 1 beta + Blm10 – Cryo EM
- 8tm4, 8tm5 – h13S – human - Cryo EM
- Proteasome Pre-15S core
- Proteasome 19S regulatory particle
- Proteasome 20S catalytic core
- 4r3o, 5le5, 5lex – h20S core
- 6r70, 6rgq, 7pg9, 7v5g, 7v5m, 8qyl, 8qyo, 8tm6 – h20S core 7 alpha 7 beta + UMP1 + chaperones 1,2 – Cryo EM
- 1iru – b20S core - bovine
- 8azk, 8fz5 – b20S core 7 alpha + 7 beta – Cryo EM
- 3une – m20S core – mouse
- 6tu3 – r20S core – rat - Cryo EM
- 7qve, 8amz – 20S – spinach - Cryo EM
- 1g0u, 3gpt, 3gpw, 5cz4 – y20S core
- 7ls5 – y20S core 7 alpha + 7 beta – Cryo EM
- 7tej – y20S core 6 alpha + 7 beta – Cryo EM
- 1ryp, 3wxr, 4qux, 4q7y, 4qv0, 4qv1, 4qv3, 4qv4, 4qv5, 4qv6, 4qv7, 4qv8, 4qv9, 4y8r, 4y9y, 4ya1, 4ya4, 5bxl, 5cza, 5d0w, 5fg7, 5fga, 6hwc, 9qaf, 9qc9 - y20S core (mutant)
- 8u7u, 9qbi, 9qcf, 9qck – y20S core 7 alpha + 7 beta (mutant) – Cryo EM
- 9d35 – y20S core 5 alpha + 3 beta + UMP1 – Cryo EM
- 9d3i – y20S core 5 alpha + 4 beta + UMP1 – Cryo EM
- 9frw – y20S/h20S core
- 1pma, 3c91, 3c92, 3j9i, 5vy3, 5vy4, 6bdf, 8f6a – Ta20S core - Themoplasma acidophilum - Cryo EM
- 6utf, 6uti, 9buz – Ta20S core subunits α+β – Cryo EM
- 8f66 – Ta20S core (mutant) – Cryo EM
- 3h4p – 20S core – Methanocaldococcus janaschii
- 1q5r, 2h6j – Re20S core (mutant) – Rhodococcus erythropolis
- 1q5q - Re20S core
- 1j2q – Af20S core - Archaeoglobus fulgidus
- 6he7 – Af20S - Cryo EM
- 6qm8 – Lt20S core – Leishmania tarentolae - Cryo EM
- 6muw – Pf20S 7 alpha + 7 beta – Plasmodium falciparum - Cryo EM
- 9y0l – Pf20S 7 alpha + 6 beta + UMP1 - Cryo EM
- 9y0k, 9y1o – Pf20S 7 alpha + 6 beta + endopeptidase - Cryo EM,br />
- 2fhg, 3mfe, 3mi0 – Mt20S core – Mycobacterium tuberculosis
- 9ce6 – Mt20S core - Cryo EM
- 9ce7, 9cee, 9ceg – Mt20S core (mutant) - Cryo EM
- 3hfa, 3mka – Mt20S core (mutant)
- 6z46 – 20S core subunits α+β – Sulfolobus acidocaldarius
- 8adn – 20S – Vairimorpha necatrix - Cryo EM
- 9f9p, 9f9t – 20S – Trypanosoma cruzi - Cryo EM
- 4r3o, 5le5, 5lex – h20S core
- Proteasome 20S core mutated pre1-1
- Immunoproteasome 20S
- 6avo, 6e5b, 7awe, 7b12 – hI20S + inhibitor - Cryo EM
- 7dr7 – bI20S - Cryo EM
- 7dr6, 7drw – bI20S + activator – Cryo EM
- 8ysx, 8yvg, 8yvp – I20S + inhibitor – dog - Cryo EM
- 3unh – mI20S
- 8ypk – mI20S + inhibitor - Cryo EM
- 3unf – mI20S + inhibitor
- 9ey9 – yI20S + drug - Cryo EM
- 4r17, 4r18, 5cgf, 5cgg, 5cgh, 5cgi, 5lai, 5laj, 5m2b, 9frw, 9fst, 9fsu, 9fsv, 9ft0, 9ft1 – yI20S + inhibitor - Cryo EM
- 4qby, 4qlq, 4qls, 4qlt, 4qlu, 4qlv - yI20S core+ peptide inhibitor
- 6avo, 6e5b, 7awe, 7b12 – hI20S + inhibitor - Cryo EM
- Preholoproteasome
- Proteasome 20S+activator protein
- 7nan, 7nao, 7nap, 7yqc, 7yqd, 8cvr, 8cxb – h20S + PA28 activator – Cryo EM
- 6kwy, 6rey, 6xmj, 7naq, 8cvs – h20S + activator PA2 – Cryo EM
- 7qxn, 7qxp, 7qxu, 7qxw, 7qxx, 7qy7, 7qya, 7qyb – h20S + activator ZFAND5 – Cryo EM
- 7nht – h20S + akirin-2 – Cryo EM
- 8bzl – h20S core+ Blm42 peptide
- 4v7o, 5nif – y20S core+ Blm10
- 1fnt, 1z7q – y20S core+PA26
- 1ya7, 1yar, 1yau, 3ipm, 3jrm, 3jse, 3jtl - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U
- 5lzp - Mt20S subunits a+b + BPA - Cryo EM
- 6bgl, 6bgo – Mt20S + activator
- 6muv, 6mux – Pf20S + activator PA28 - Cryo EM
- 6he5, 6he8, 6he9, 6hea, 6hec, 6hed – Af20S + PAN – Cryo EM
- 6utg, 6uth, 6utj – Ta20S core subunits α+β + activator PA26 – Cryo EM
- 7nan, 7nao, 7nap, 7yqc, 7yqd, 8cvr, 8cxb – h20S + PA28 activator – Cryo EM
- Proteasome 20S complex
- 4r67 – h20S + cancer drug
- 5ley, 5lez, 5lf0, 5lf1, 5lf3, 5lf4, 5lf6, 5lf7 - h20S + inhibitor
- 8ud9, 9hmn, 9rkz, 9yuz - h20S + inhibitor – Cryo EM
- 5a0q - h20S + substrate analog
- 9qon, 9qoo – h20S 7 alpha + importin-9 + akirin-2 – Cryo EM
- 9qvx – h20S 7 alpha + 7 beta + peptide – Cryo EM
- 8fz6 – b20S core + PI31 inhibitor – Cryo EM
- 3unb – m20S + inhibitor
- 1jd2, 1g65, 2f16, 2fak, 2gpl, 2zcy, 3bdm, 3d29, 3dy3, 3dy4, 3e47, 3gpj, 3hye, 3mg0, 3mg4, 3mg6, 3mg7, 3mg8, 3oeu, 3oev, 3okj, 3sdi, 3sdk, 3shj, 3un4, 3un8, 4eu2, 4fzc, 4fzg, 4gk7, 4inr, 4int, 4inu, 4jsq, 4jsu, 4jt0, 4qwx, 4qzz, 4r02, 4rur, 4y69, 4y6a, 4y6v, 4y6z, 4y70, 4y74, 4y75, 4y77, 4y78, 4y7w, 4y7x, 4y7y, 4y80, 4y81, 4y82, 4y84, 4y8g, 4y8h, 4y8i, 4y8j, 4y8k, 4y8l, 4y8m, 4y8n, 4y8o, 4y8p, 4y8q, 4y8s, 4y8t, 4y8u, 4y9z, 4ya0, 4ya2, 4ya3, 4ya5, 4ya7, 4ya9, 5ahj, 5bou, 5dki, 5dkj, 5jhr, 5jhs, 5l52, 5l54, 5l55, 6gop, 6h39, 6htb, 6htc, 6htd, 6htp, 6htr, 6hub, 6huc, 6huq, 6huu, 6huv, 6hv3, 6hv4, 6hv5, 6hv7, 6hva, 6hvr, 6hvs, 6hvt, 6hvu, 6hvv, 6hvw, 6hvx, 6hvy, 6h39, 6hw0, 6hw3, 6hw4, 6hw5, 6hw6, 6hw7, 6hw8, 6hw9, 6hwa, 6hwb, 7o2l, 8bw1, 8ohz, 8oi1, 8olr, 8rhj, 8rhk, 8rhl, 9aw3, , 9aw5, 9aw6, 9ft0, 9ft1 – y20S core+inhibitor
- 4qxj, 4qz0, 4qz1, 4qz2, 4qz3, 4qz4, 4qz5, 4qz6, 4qz7, 4qzw, 4qzx, 4r00, 4r02, 5d0t, 5fgh, 6g8n, 6g8m, 6g7f, 6hwf, 9qai, 9qbe, 9qbo, 9qby, 9qd2 – y20S (mutant) + inhibitor
- 9fst, 9fsu, 9fsv – y20S/h20S core+inhibitor
- 4hnp, 4hrc, 4hrd, 4lqi, 4ltc, 4q1s, 6zou, 6zp6, 6zp8 - y20S core + antibiotics
- 9qb1, 9s78 - y20S core + drug
- 9qb4, 9qbi, 9qbw, 9qdf, 9qds - y20S core (mutant) + drug
- 4nnn, 4nnw, 4no1, 4no6, 4no8, 4no9 - y20S core+ peptide inhibitor
- 5cz6, 5cz7 - y20S (mutant) + peptide inhibitor
- 7teo – y20S core + FUB1 – Cryo EM
- 2fhh, 3h6f, 3h6i, 3hf9, 3krd, 6ocw, 6ocz, 6ode, 6wnk – Mt20S core+inhibitor
- 9ce8 – Mt20S core + drug – Cryo EM
- 8d6v, 8d6w, 8d6x, 8d6y – Mt20S core+ ATPase + ATP – Cryo EM
- 3nzj, 3nzw, 3nzx - y20S + TMC-95A mimic ligand
- 3tdd, 4j70, 4qvl, 4qw4, 4z1l – y20S + cancer drug
- 4qvm, 4qvn, 4qvp, 4qvq, 4qvv, 4qvw, 4qvy, 4qw0, 4qw1, 4qw3, 4qw5, 4qw6, 4qw7, 4qwf, 4qwg, 4qwi, 4qwj, 4qwk, 4qwl, 4qwr, 4qws, 4qwu, 5bxn, 5cz5, 5cz8, 5cz9, 5d0s, 5d0v, 5d0x, 5d0z, 5fgd, 5fge, 5fgf, 5fgg, 5fgi, 5fhs, 6hwd, 6hwe - y20S (mutant) + cancer drug
- 4x6z - y20S + modulator
- 5gjq - y20S + ubiquitin carboxyl hydrolase 14 + polyubiquitin
- 5l5a - y20S + h20S beta5i
- 5ltt - y20S + h20S beta5i + inhibitor
- 5l5b, 5l5r - y20S + h20S beta5i + h20S beta6
- 5l5w - y20S + h20S beta5c + h20S beta6
- 5l5x, 5l60, 5l61 - y20S + h20S beta5c + h20S beta6 + inhibitor
- 5l5y, 5l5z - y20S + h20S beta5c + h20S beta6 + cancer drug
- 5l5d, 5l5h, 5l5i, 5l5j, 5l5o, 5l5p, 5l5q, 5l5s, 5l5t, 5l5u, 5l5v, 5l62, 5l63, 5l64, 5l68, 5l69, 5l6a, 5l6c - y20S + h20S beta5i + h20S beta6 + inhibitor
- 5l5e, 5l5f - y20S + h20S beta5i + h20S beta6 + cancer drug
- 5l65, 5l66 - y20S + m20S beta5i + m20S beta6 + cancer drug
- 5l67, 5l6b - y20S + m20S beta5i + m20S beta6 + inhibitor
- 5tho, 5trg, 5trr, 5trs, 5try, 5ts0 - Mt20S + peptide
- 6qm7 – Lt20S + leishmania drug – Cryo EM
- 6td5 – Lt20S + inhibitor – Cryo EM
- 7lxt – Pf20S + cancer drug – Cryo EM
- 5fmg, 7lxu, 7lxv, 8g6e, 8g6f, 8w2f, 9o3e, 9o3f, 9yuy – Pf20S + inhibitor – Cryo EM
- 6tcz, 7zyj, 8olu – 20S + inhibitor - Leishmania donovani – Cryo EM
- 8oix, 8p0t – 20S + inhibitor - Trichomonas vaginalis – Cryo EM
- 8f7k – Ta20S core + peptide – Cryo EM
- 4r67 – h20S + cancer drug
- Proteasome partial 20S particle
- 2kqz, 2kr0 – hPRTS ubiquitin receptor domain
- 2ku1, 2ku2 – Taa-PRTS chains A-G
- 3fp9 – MtATPase chains A-L
- 7pxa - MtPRTS α+β subunits + ATPase – Cryo EM
- 7pxc, 7pxd - MtPRTS α+β subunits + ATPase + Pup – Cryo EM
- 2jay – MtPRTS β subunit
- 1j2p – AfPRTS α subunit
- 5nyw – PRTS β subunit – Yersinia bercovieri
- 2kqz, 2kr0 – hPRTS ubiquitin receptor domain
- Proteasome 26S particle regulatory non-ATPase subunit 1
- Proteasome 26S particle regulatory non-ATPase subunits 1,2
- 8usd - hPRTS regulatory non-ATPase subunits 1,2 + Nub1 + regulatory subunits 4,7 – Cryo EM
- 8usd - hPRTS regulatory non-ATPase subunits 1,2 + Nub1 + regulatory subunits 4,7 – Cryo EM
- Proteasome 26S particle regulatory non-ATPase subunits 1,13
- Proteasome 26S particle regulatory non-ATPase subunit 2 or Rpn1
- Proteasome 26S particle regulatory non-ATPase subunit 4 ofr Rpn10
- 1p9c – hPRTS regulatory non-ATPase subunit 4 C-terminal
- 1p9d - hPRTS regulatory non-ATPase subunit 4 C-terminal + HHR23A ubiquitin-like domain
- 1uel - hPRTS regulatory non-ATPase subunit 4 C-terminal + HHR23A ubiquitin-like domain - NMR
- 1yx4 - hPRTS regulatory non-ATPase subunit 4 – NMR
- 1yx5, 1yx6, 2kde, 2kdf, 6mun - hPRTS regulatory non-ATPase subunit 4+ubiquitin – NMR
- 6u19 - hPRTS regulatory non-ATPase subunit 4 RAZUL domain + ubiquitin protein ligase E3A peptide – NMR
- 8j4a, 8jtk, 8jtl, 8pfd - PRTS regulatory non-ATPase subunit 4 + SAP05 – Arabidosis thaliana
- 2x5n - fyPRTS regulatory non-ATPase subunit 4 VWA domain – fission yeast
- 5ln1 - yPRTS regulatory non-ATPase subunit 4 + polyubiquitin
- 1p9c – hPRTS regulatory non-ATPase subunit 4 C-terminal
- Proteasome 26S particle regulatory non-ATPase subunit 5 or Rpn5
- 5zmr - yPRTS regulatory non-ATPase subunit 5 N terminal – NMR
- 5zmr - yPRTS regulatory non-ATPase subunit 5 N terminal – NMR
- Proteasome 26S particle regulatory non-ATPase subunit 7 or Rpn9
- 2o95, 2o96 - hPRTS regulatory non-ATPase subunit 7
- 3vlf - yPRTS regulatory non-ATPase subunit 7 + DNA mismatch repair protein
- 2mr3 - yPRTS regulatory non-ATPase subunit 7 – NMR
- 2mqw - yPRTS regulatory non-ATPase subunit 7 N terminal – NMR
- 2mri - yPRTS regulatory non-ATPase subunit 7 C terminal – NMR
- 2o95, 2o96 - hPRTS regulatory non-ATPase subunit 7
- Proteasome 26S particle regulatory non-ATPase subunit 8
- Proteasome 26S particle regulatory non-ATPase subunits 8,11
- Proteasome 26S particle regulatory non-ATPase subunit 11
- Proteasome 26S particle regulatory non-ATPase subunit 12
- 4b0z - fyPRTS regulatory non-ATPase subunit 12
- 4b0z - fyPRTS regulatory non-ATPase subunit 12
- Proteasome 26S particle regulatory non-ATPase subunit 13 or ADRM1
- Proteasome 26S particle regulatory non-ATPase subunit 14
- 3vl1 - yPRTS regulatory non-ATPase subunit 14 (mutant)
- 3vl1 - yPRTS regulatory non-ATPase subunit 14 (mutant)
- For hPRTS regulatory non-ATPase subunit 10 or Gankyrin see Ankyrin
- Proteasome 26S particle Dss1 subunit
- Proteasome 26S particle SEM1 subunit
- 28wy, 28xa, 28xb - hPRTS subunit SEM1 + SAC3D1 + PCID2 – Cryo EM
- 8r7j, 8r7k, 9upc - hPRTS subunit SEM1 in TREX-2 complex – Cryo EM
- 9dlp, 9t6n, 9opb - hPRTS subunit SEM1 + spliceosome RNA helicase + Germinal-center associated nuclear protein + PCI-domain containing protein – Cryo EM
- 9dlr, 9dlv, 9t6l - hPRTS subunit SEM1 + spliceosome RNA helicase + leukocyte receptor cluster + PCI-domain containing protein – Cryo EM
- 9rv1 - hPRTS subunit SEM1 + spliceosome RNA helicase + + PCI-domain containing protein + SAC3 domain containing protein – Cryo EM
- 3jck - hPRTS subunit SEM1 + Lid complex – Cryo EM
- 3t5v, 4trq, 5g5p, 5l3t - yPRTS subunit SEM1 + nuclear mRNA export proteins SAC3 and THP1<br /
- 5ubp - yPRTS subunit SEM1 + nuclear mRNA export protein THP1 + leucine permease transcriptional regulator
- 7ewf, 7ewm - yPRTS subunit SEM1 + CSN12 + THP3
- 8u8c - yPRTS subunit SEM1 + SAC3 + THP1 + SUB2
- 8u8d, 8u8e - yPRTS subunit SEM1 + RNA helicase + nuclear mRNA export factor + THP1 – Cryo EM
- 28wy, 28xa, 28xb - hPRTS subunit SEM1 + SAC3D1 + PCID2 – Cryo EM
- Proteasome 26S particle
- 5gjr, 5l4g, 5ln3, 5t0c, 5t0g, 5t0h, 5t0i, 5t0j, 5vfo, 5vfp, 5vfq, 5vfr, 5vfs, 5vft, 5vfu, 5vgz, 5vhf, 5vhh, 5vhi, 5vhj, 5vhm, 5vhn, 5vho, 5vhp, 5vhq, 5vhr, 5vhs, 8jri, 9iwr - h26S - Cryo EM
- 8cvt, 9nkf – h26S + ATP - Cryo EM
- 6msb, 6msd, 6mse, 6msg, 6msh, 6msj, 6msk, 9u7r – h26S + ADP + ATP - Cryo EM
- 5m32, 9vue, 9vuf, 9vug] - h26S + inhibitor - Cryo EM
- 8jrt, 8jti, 8k0g, 9k4j, 9k4k, 9k4l, 9k4m, 9k4o, 9k4p, 9k4r, 9k4s, 9k4t, 9k4u, 9k4v, 9k4w, 9k4x, 9k4y, 9k4z, 9k50, 9k51, 9k53, 9k54, 9k55, 9k56, 9k57, 9k58, 9k59, 9k5a, 9k5b, 9k5c, 9k5d, 9k5e – h26S + ubiquitin – Cryo EM
- 6wjd, 6wjn – h26S + ubiquitin + E3 ubiquitin ligase – Cryo EM
- 9heu, 9szt, 9szv – h26S + Bag1 + ADP + ATP - Cryo EM
- 7w37, 7w38, 7w39, 7w3a, 7w3b, 7w3c, 7w3f, 7w3g, 7w3h, 7w3i, 7w3j, 7w3k, 7w3m – h26S + USP14 – Cryo EM
- 9bui, 9bv1, 9bv2, 9bv3, 9m2w, 9mbp, 9mbq, 9u3l, 9u4m, 9uf8, 9ug9, 9wbg, 22mm – h26S + midnolin – Cryo EM
- 9w39 – h26S + midnolin + ubiquitin – Cryo EM
- 9nki, 9nkg – h26S + midnolin + SEM1 + ATP + ADP – Cryo EM
- 9nkj – h26S + SEM1 + ATP + ADP – Cryo EM
- 9e8h, 9e8i, 9pmo, 9pmq – h26S + TXNL1 – Cryo EM
- 8usb, 8usc, 9e8k, 9pdl, 9pf1 – h26S + Nub1/FAT10 + ATP + ADP – Cryo EM
- 9bw4, 9e8g, 9e8j, 9e8l, 9e8n, 9e8o – h26S + Nub1/FAT10 + TXNL1 + ATP + ADP – Cryo EM
- 8zzq – h26S + Ecm29 – Integrative
- 6epc, 6epd, 6epe, 6epf – r26S - Cryo EM
- 3j47, 3jco, 3jcp, 4cr2, 4cr3, 4cr4, 5mpc, 5wvi, 6fvt, 6fvu, 6fvv, 6fvw, 6fvx, 6fvy 6j2c, 6j2n, 6j2q, 6j2x, 6j30 – y26S – Cryo EM
- 5wvk - y26S + ADP - Cryo EM
- 5mp9, 5mpa, 5mpd, 5mpe - y26S + ATP - Cryo EM
- 9cgc - y26S + ATP+ ADP - Cryo EM
- 5mpb - y26S + AMPPNP - Cryo EM
- 4g4s – y26S + proteasome assembly chaperon 1 & 2
- 5a5b - y26S + UBP6 - Cryo EM
- 6ef0, 6ef1, 6ef2, 6ef3 – y26S + ubiquitin-L40 – Cryo EM
- 7qo3 – y26S + Ubp6 – Cryo EM
- 7qo4 – y26S + Ubp6 + UbVS – Cryo EM
- 7qo5, 7qo6 – y26S + Rpt1 + Rk + Ubp6 + UbVS – Cryo EM
- 5gjr, 5l4g, 5ln3, 5t0c, 5t0g, 5t0h, 5t0i, 5t0j, 5vfo, 5vfp, 5vfq, 5vfr, 5vfs, 5vft, 5vfu, 5vgz, 5vhf, 5vhh, 5vhi, 5vhj, 5vhm, 5vhn, 5vho, 5vhp, 5vhq, 5vhr, 5vhs, 8jri, 9iwr - h26S - Cryo EM