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[[Image:2wwe.png|left|200px]]


{{STRUCTURE_2wwe|  PDB=2wwe  |  SCENE= }}
==Crystal structure of the phox homology domain of human phosphoinositide-3-kinase-C2-gamma==
 
<StructureSection load='2wwe' size='340' side='right'caption='[[2wwe]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
===CRYSTAL STRUCTURE OF THE PHOX HOMOLOGY DOMAIN OF HUMAN PHOSPHOINOSITIDE-3-KINASE-C2-GAMMA===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2wwe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WWE FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wwe OCA], [https://pdbe.org/2wwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wwe RCSB], [https://www.ebi.ac.uk/pdbsum/2wwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wwe ProSAT]</span></td></tr>
[[2wwe]] is a 1 chain structure of [[Phosphoinositide 3-Kinases]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WWE OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/P3C2G_HUMAN P3C2G_HUMAN] Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers (By similarity). May play a role in SDF1A-stimulated chemotaxis (By similarity).[UniProtKB:O70167][UniProtKB:O70173]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/2wwe_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wwe ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Phosphoinositide 3-Kinases|Phosphoinositide 3-Kinases]]
*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Berg, S Van Den.]]
[[Category: Arrowsmith CH]]
[[Category: Berglund, H.]]
[[Category: Berglund H]]
[[Category: Bountra, C.]]
[[Category: Bountra C]]
[[Category: Collins, R.]]
[[Category: Collins R]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Flodin, S.]]
[[Category: Flodin S]]
[[Category: Flores, A.]]
[[Category: Flores A]]
[[Category: Graslund, S.]]
[[Category: Graslund S]]
[[Category: Hammarstrom, M.]]
[[Category: Hammarstrom M]]
[[Category: Johansson, A.]]
[[Category: Johansson A]]
[[Category: Johansson, I.]]
[[Category: Johansson I]]
[[Category: Kallas, A.]]
[[Category: Kallas A]]
[[Category: Karlberg, T.]]
[[Category: Karlberg T]]
[[Category: Kotyenova, T.]]
[[Category: Kotyenova T]]
[[Category: Kotzch, A.]]
[[Category: Kotzch A]]
[[Category: Kraulis, P.]]
[[Category: Kraulis P]]
[[Category: Markova, N.]]
[[Category: Markova N]]
[[Category: Moche, M.]]
[[Category: Moche M]]
[[Category: Nielsen, T K.]]
[[Category: Nielsen TK]]
[[Category: Nordlund, P.]]
[[Category: Nordlund P]]
[[Category: Nyman, T.]]
[[Category: Nyman T]]
[[Category: Persson, C.]]
[[Category: Persson C]]
[[Category: Roos, A K.]]
[[Category: Roos AK]]
[[Category: Schuler, H.]]
[[Category: Schuler H]]
[[Category: Schutz, P.]]
[[Category: Schutz P]]
[[Category: Sgc , Structural Genomics Consortium Stockholm]]
[[Category: Siponen MI]]
[[Category: Siponen, M I.]]
[[Category: Svensson L]]
[[Category: Svensson, L.]]
[[Category: Thorsell AG]]
[[Category: Thorsell, A G.]]
[[Category: Tresaugues L]]
[[Category: Tresaugues, L.]]
[[Category: Van Der Berg S]]
[[Category: Wahlberg, E.]]
[[Category: Wahlberg E]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Welin, M.]]
[[Category: Welin M]]
[[Category: Wisniewska, M.]]
[[Category: Wisniewska M]]
[[Category: Atp-binding]]
[[Category: Class 2 pi3k]]
[[Category: Kinase]]
[[Category: Membrane]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Pik3c2g]]
[[Category: Px-domain]]
[[Category: Transferase]]

Latest revision as of 10:18, 20 December 2023

Crystal structure of the phox homology domain of human phosphoinositide-3-kinase-C2-gamma

2wwe, resolution 1.25Å

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