Phosphoinositide 3-kinase 3D structures

3D Structures of PI3K

Updated on 19-May-2026

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• Class I p85α
  • 2iug, 2iuh, 2iui – hPI3KI p85α N-terminal+ peptides - human
    
  • 1h9o – hPI3KI p85α C-terminal + PDGFR peptide
    
  • 2vly - hPI3KI p85α+ABD
    
  • 1pic - hPI3K p85α subunit SH2 domain + β-platelet-derived growth factor receptor peptide – NMR
    
  • 1pht, 3i5s, 3i5r - hPI3KI p85α SH3 domain
    
  • 1pks, 1pkt - hPI3KI p85α SH3 domain – NMR
    
  • 1pbw, 2xs6 - hPI3K p85α subunit RhoGAP domain
    
  • 1bfi, 1bfj, 2pna, 2pnb - bPI3KI p85α SH2 domain – bovine – NMR
    
  • 1oo3 - bPI3KI p85α SH2 domain (mutant) – NMR
    
  • 1oo4 - bPI3KI p85α SH2 domain (mutant) + PDGFR peptide – NMR
    
  • 1qad - bPI3KI p85α SH2 domain
    
  • 1pnj, 2pni – bPI3K p85α subunit SH3 domain – NMR
    
  • 1fu5, 1fu6 – PI3KI p85α + peptides – NMR – rat
    
• Class I p85β
  • 3mtt, 3o5z – hPI3KI p85β
    
  • 2kt1 - hPI3KI p85β SH3 domain
    
  • 6ox7, 6u28 – hPI3KI p85β + influenza NS1 protein
    
  • 3l4q – bPI3KI p85β + influenza NS1 protein
    
• Class II
  • 2wwe – hPI3KIIγ PHOX homology domain
    
  • 2ar5, 2iwl, 2rea, 2red, 6bub – hPI3KII PX domain
    
  • 2b3r, 6bty, 6btz - hPI3KII C2 domain
    
  • 6bu0 - hPI3KII C2 domain + IP6
    
• Class III
  • 3ihy, 6hog, 9e4v – hPI3KIII p100
    
  • 11mm, 11yc, 3ls8, 5enl, 5ann, 9dkp, 9nin, 9orm, 9zf4 – hPI3KIII p100 + inhibitor
    
  • 6i3u – hPI3KIII p100 (mutant) + inhibitor
    
  • 2x6f, 2x6h, 2x6i, 2x6j, 2x6k – PI3KIII + inhibitors – Drosophila melanogaster
    
• Type I PI3K (Phosphatidylinositol-4,5-bisphosphate 3-kinase)
• Type I PI3K p110α+ p85α
  • 3hhm - hTI-PI3K p110α + p85α SH2 domain + wortmannin
    
  • 3hiz, 4jps - hTI-PI3K p110α (mutant) + p85α
    
  • 2rd0, 4l1b, 6nct, 7pg5 - hTI-PI3K p110α + p85α
    
  • 7myn - hTI-PI3K p110α + p85α – Cryo EM
    
  • 5dxh, 5sw8, 5swg, 5swo, 5swp, 5swr, 5swt, 5sx8, 5sx9, 5sxa, 5sxb, 5sxc, 5sxd, 5sxe, 5sxf, 5sxi, 5sxj, 5sxk, 5xgh, 5xgi, 5xgj, 8tdu, 9lwq - hTI-PI3K p110α + p85α + inhibitor
    
  • 8ilr, 8ils, 8ilv, 8w9a, 8w9b - hTI-PI3K p110α + p85α + inhibitor – Cryo EM
    
  • 4zop, 5fi4, 5itd, 5ukj, 5ul1, 7tz7, 8sbc, 8tgd, 8v8v, 9lwr, 9lws - hTI-PI3K p110α (mutant) + p85α + inhibitor
    
  • 5uk8 - hTI-PI3K p110α (mutant) + p85α (mutant) + inhibitor
    
  • 7myo - hTI-PI3K p110α + p85α + inhibitor – Cryo EM
    
  • 8am0 - hTI-PI3K p110α + p85α + drug
    
  • 7pg6 - hTI-PI3K p110α + p85α + activaor
    
  • 7bl1, 9mhf, 9mhg, 9mhh - hTI-PI3K p110α + p85α + beclin + Ras-related protein + GTP – Cryo EM
    
  • 9zpc, 9zpd - hTI-PI3K p110α + p85α + beclin + UV resistance-associated gene protein + GDP – Cryo EM
    
  • 4ovu - hTI-PI3K p110α + p85α SH2 domain
    
  • 4ovv - hTI-PI3K p110α + p85α SH2 domain + phosphatidylinositol-4,5-bisphosphate
    
  • 4l23, 4l2y - hTI-PI3K p110α + p85α + inhibitor
    
  • 4waf - hTI-PI3K p110α (mutant) + p85α (mutant) + inhibitor
    
  • 2v1y - bTI-PI3K p110α +h-p85α
    
• Type I PI3K p110α
  • 4tuu, 4tv3, 8bfu - hTI-PI3K p110α catalytic subunit 105-1048
    
  • 2enq - hTI-PI3K p110α C2 domain 331-481
    
  • 6vo7, 9cmk, 9cml - hTI-PI3K p110α RBD 157-300
    
  • 3zim, 4a55, 4oys, 4ph4, 4uwf, 4uwg, 4uwh, 4uwk, 4uwl, 4yxn, 5dxt, 5ubr, 6gvf, 6gvg, 6gvh, 6gvi, 6oac, 6pys, 7k6m, 7k6n, 7k6o, 7k71, 7mlk, 7r9v, 7r9y, 8exo, 8exu, 8exv, 8sbj, 8sc8 - hTI-PI3K p110α catalytic subunit + inhibitor
    
  • 9b4u, 9e8m - hTI-PI3K p110α catalytic subunit (mutant) + inhibitor
    
  • 8ow2 - hTI-PI3K p110α catalytic subunit + activator
    
  • 8exl - hTI-PI3K p110α catalytic subunit + drug
    
  • 8gua, 8gub, 8gud - hTI-PI3K p110α catalytic subunit (mutant) + drug – Cryo EM
    
  • 9b4s, 9b4t, 9c15, 9cmv - hTI-PI3K p110α catalytic subunit (mutant) + Ras-related protein
    
  • 8dcp, 8dcx, 8dd4, 8dd8 - hTI-PI3K p110α catalytic subunit + regulatory subunit 3-724 + nanobody – Cryo EM
    
  • 7cio - hTI-PI3K p110α C2 domain + CTLA-4
    
  • 7bi4 - mTI-PI3K p110α C2 domain (mutant)
    
  • 7bi9, 7z74, 7z75, 8a9i - mTI-PI3K p110α C2 domain + inhibitor
    
  • 7bi6 - mTI-PI3K p110α C2 domain + ATP
    
• Type I PI3K p110β
  • 2y3a - hTI-PI3K p110β + p85β + drug
    
  • 4bfr - TI-PI3K p110β + inhibitor – mouse
    
• Type I PI3K p110γ or class 1B
  • 3lj3, 5oq4, 6c1s – hTI-PI3K p110γ + pyridine derivative inhibitor
    
  • 3l54 – hTI-PI3K p110γ + quinoline derivative
    
  • 3l08 – hTI-PI3K p110γ + GSK2126458
    
  • 3ibe– hTI-PI3K p110γ + pyrazolopyrimidine
    
  • 1e7u, 1e7v, 1e8w, 1e8x, 1e8y, 1e8z, 1e90, 2a4z, 2a5u, 2v4l, 3apc, 3apd, 3apf, 3ene, 3mjw, 3nzs, 3nzu, 3p2b, 3qaq, 3qar, 3r7q, 3r7r, 3s2a, 3sd5, 3t8m, 3tis, 3tl5, 3zvv, 3zw3, 4anu, 4anv, 4anw, 4anx, 4aof, 4dk5, 4f1s, 4fa6, 4fad, 4fhj, 4fhk, 4fjy, 4fjz, 4flh, 4ful, 4g11, 4gb9, 4hle, 4hvb, 4j6i, 4ps3, 4ps7, 4ps8, 4urk, 4wwn, 4wwo, 4wwp, 4xx5, 4xz4, 5eds, 5g2n, 5g55, 5jha, 5jhb, 5kae, 5t23, 6fh5, 6gq7, 6q6y, 6q73, 6q74, 6t3b, 6t3c, 6xrl, 6xrm, 6xrn, 6ykg, 7jx0, 7kke, 7jwz, 7rsj, 7rsp, 7rsv, 7z61, 8rxr, 9gg9 – hTI-PI3K p110γ + inhibitor
    
  • 3tjp, 4ezj, 4ezk, 4ezl, 4kz0, 4kzc - hTI-PI3K p110γ (mutant) + inhibitor
    
  • 7jwe – hTI-PI3K p110γ + drug
    
  • 3dpd, 6aud – hTI-PI3K p110γ + oxazines inhibitor
    
  • 3dbs– hTI-PI3K p110γ + GDC0941
    
  • 3csf, 3cst – hTI-PI3K p110γ + organourethenium inhibitor
    
  • 2chw, 2chx, 2chz – hTI-PI3K p110γ + PIK-39 inhibitor
    
  • 3l13, 3l16, 3l17, 3ml8, 3ml9, 3oaw, 3pre, 3prz, 3ps6, 3qjz, 3qk0 – hTI-PI3K p110 + PI3K/mTOR dual inhibitor
    
  • 1he8 - hTI-PI3K p110 + transforming protein P21/H-RAS-1 effector domain
    
  • 7mez - hTI-PI3K p110 + p101 – cryo EM
    
  • 8dp0 - hTI-PI3K p110 catalytic subunit + nanobody – cryo EM
    
  • 8aj8 - pTI-PI3K p110g catalytic subunit + regulatory subunit - pig
    
  • 8so9 - pTI-PI3K p110g catalytic subunit + regulatory subunit – Cryo EM
    
  • 8soa, 8sob, 8soc, 8sod, 8soe - pTI-PI3K p110g catalytic subunit + regulatory subunit + G(I) + nucleotide – Cryo EM
    
• Type I PI3K p110δ
  • 2x38 – hTI-PI3K p110δ + IC87114
    
  • 2wxf, 2wxg, 2wxh, 2wxi, 2wxj, 2wxk, 2wxl, 2wxm, 2wxn, 2wxo, 2wxp, 2wxq, 2wxr, 4ajw, 6g6w, 6oco, 6ocu, 6pyr, 6pyu, 7jis, 7jiu, 7lm2 – hTI-PI3K p110δ + inhibitor
    
  • 6dgt, 6eyz, 6ez6, 6ftn, 6gy0, 6hi1, 6hi2, 6hi9, 6mul, 6mum, 6tnr, 6tns, 6zaa, 6zac, 6zad, 7oi4, 7oij 7oil, 7ois 7pop, 7por, 7pos, 7pot – mTI-PI3K p110δ + inhibitor
    
• Type I PI3K p150
  • 9c82 – hTI-PI3K p150 + p100 + ULK1C + C1 – Cryo EM
    
• Type I PI3K p100
  • 13bv – hTI-PI3K p100 + C1 – Cryo EM
    
• PI3K MavQ
  • 7m7a – MavQ – Legionella pneumophila
    

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