3upi: Difference between revisions
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==Synthesis of novel 4,5-dihydrofurano indoles and their evaluation as HCV NS5B polymerase inhibitors== | |||
<StructureSection load='3upi' size='340' side='right'caption='[[3upi]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3upi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_isolate_HC-J4 Hepatitis C virus isolate HC-J4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UPI FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0C2:(3S)-6-(2,5-DIFLUOROBENZYL)-3-METHYL-N-(METHYLSULFONYL)-8-(2-OXO-1,2-DIHYDROPYRIDIN-3-YL)-3,6-DIHYDRO-2H-FURO[2,3-E]INDOLE-7-CARBOXAMIDE'>0C2</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3upi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3upi OCA], [https://pdbe.org/3upi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3upi RCSB], [https://www.ebi.ac.uk/pdbsum/3upi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3upi ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The synthesis of substituted 3,4-dihydrofuranoindoles is reported. These new indole compounds were used to synthesize potent HCV NS5B inhibitors. The binding mode of the dihydrofuranoindole-derived inhibitors was established via X-ray crystallographic studies. | |||
Synthesis of New 4,5-Dihydrofuranoindoles and Their Evaluation as HCV NS5B Polymerase Inhibitors.,Velazquez F, Venkatraman S, Lesburg CA, Duca J, Rosenblum SB, Kozlowski JA, Njoroge FG Org Lett. 2012 Jan 20;14(2):556-9. Epub 2012 Jan 5. PMID:22220815<ref>PMID:22220815</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 3upi" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[RNA polymerase|RNA polymerase]] | *[[RNA polymerase 3D structures|RNA polymerase 3D structures]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
[[Category: Hepatitis | </StructureSection> | ||
[[Category: | [[Category: Hepatitis C virus isolate HC-J4]] | ||
[[Category: Duca | [[Category: Large Structures]] | ||
[[Category: Kozlowski | [[Category: Duca JS]] | ||
[[Category: Lesburg | [[Category: Kozlowski JA]] | ||
[[Category: Njoroge | [[Category: Lesburg CA]] | ||
[[Category: Rosenblum | [[Category: Njoroge FG]] | ||
[[Category: Velazquez | [[Category: Rosenblum SB]] | ||
[[Category: Venkataraman | [[Category: Velazquez F]] | ||
[[Category: Venkataraman S]] | |||
Latest revision as of 02:31, 21 November 2024
Synthesis of novel 4,5-dihydrofurano indoles and their evaluation as HCV NS5B polymerase inhibitors
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