1y5m: Difference between revisions
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==The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes== | |||
<StructureSection load='1y5m' size='340' side='right'caption='[[1y5m]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1y5m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y5M FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y5m OCA], [https://pdbe.org/1y5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y5m RCSB], [https://www.ebi.ac.uk/pdbsum/1y5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y5m ProSAT]</span></td></tr> | ||
[[1y5m]] is a 2 chain structure | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/DHI1_MOUSE DHI1_MOUSE] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y5/1y5m_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y5m ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]] | *[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Clogston | [[Category: Clogston CL]] | ||
[[Category: Delaney | [[Category: Delaney JM]] | ||
[[Category: Jordan | [[Category: Jordan SR]] | ||
[[Category: Nybo | [[Category: Nybo RE]] | ||
[[Category: Osslund | [[Category: Osslund TD]] | ||
[[Category: Plant | [[Category: Plant MH]] | ||
[[Category: Xiong | [[Category: Xiong F]] | ||
[[Category: Zhang | [[Category: Zhang J]] | ||
Latest revision as of 08:55, 14 February 2024
The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes
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