CutA1: Difference between revisions

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'''CutA1''' is involved in copper tolerance in E. coli. In mammals it is implicated in the anchoring of acetylcholinesterase in the neural cell membrane. The thermostability of CutA1 from Pyrococcus horikoshii is extremely high. ~~For more details see~~ [[Divalent cation tolerant protein CUTA from Homo sapiens O60888]].

'''CutA1''' or '''periplasmic divalent cation tolerance protein''' is involved in copper tolerance in ''E. coli''. In mammals it is implicated in the anchoring of acetylcholinesterase in the neural cell membrane. The thermostability of CutA1 from ''Pyrococcus horikoshii'' is extremely high.<ref>PMID:14706845</ref> See [[Divalent cation tolerant protein CUTA from Homo sapiens O60888]].

== Structural highlights ==

The <scene name='50/508403/Cv/2'>copper ion is bound to Asp and Lys residues</scene>.

==3D structures of CutA1==

[[CutA1 3D structures]]

~~[[1kr4]], [[1o5j]], [[1vhf]] – TmCutA – ''Thermotoga maritima''~~

</StructureSection>

~~[[1nza]], [[1v6h]] – CutA – ''Thermus thermophilus'' ~~

~~[[1p1l]] – CutA – ''Archaeoglobus fulgidus'' ~~

~~[[1naq]] – EcCutA – ''Escherichia coli'' ~~

~~[[3aa8]], [[3aa9]], [[3ah6]] - EcCutA (mutant) ~~

~~[[1osc]] – CutA – rat ~~

~~[[1xk8]] – CutA – human ~~

~~[[2zom]] - CutA - rice ~~

~~[[1j2v]] – PhCutA – ''Pyrococcus horikoshii'' ~~

~~[[3gsd]] - CutA – ''Yersinia pestis'' ~~

~~[[3opk]] - CutA – ''Salmonella enterica'' ~~

~~[[2e66]] - PhCutA (mutant)~~

~~===CutA1 binary complex===~~

~~[[1uku]], [[1v99]] – PhCutA + Cu ~~

== References ==

~~[[1v9b]] - PhCutA + Co~~

[[~~1umj~~]] ~~- PhCutA + guanidine~~

[[Category:Topic Page]]

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+<StructureSection load='1uku' size='350' side='right' caption='CutA1 complex with copper (PDB entry [[1uku]])' scene='50/508403/Cv/1'>
-'''CutA1''' is involved in copper tolerance in E. coli.  In mammals it is implicated in the anchoring of acetylcholinesterase in the neural cell membrane.  The thermostability of CutA1 from Pyrococcus horikoshii is extremely high.  For more details see [[Divalent cation tolerant protein CUTA from Homo sapiens O60888]].
+'''CutA1''' or '''periplasmic divalent cation tolerance protein''' is involved in copper tolerance in ''E. coli''.  In mammals it is implicated in the anchoring of acetylcholinesterase in the neural cell membrane.  The thermostability of CutA1 from ''Pyrococcus horikoshii'' is extremely high.<ref>PMID:14706845</ref>  See [[Divalent cation tolerant protein CUTA from Homo sapiens O60888]].
+== Structural highlights ==
+The <scene name='50/508403/Cv/2'>copper ion is bound to Asp and Lys residues</scene>.
 ==3D structures of CutA1==
+[[CutA1 3D structures]]
-[[1kr4]], [[1o5j]], [[1vhf]] – TmCutA – ''Thermotoga maritima''<br />
+</StructureSection>
-[[1nza]], [[1v6h]] – CutA – ''Thermus thermophilus''<br />
-[[1p1l]] – CutA – ''Archaeoglobus fulgidus''<br />
-[[1naq]] – EcCutA – ''Escherichia coli''<br />
-[[3aa8]], [[3aa9]], [[3ah6]] - EcCutA (mutant)<br />
-[[1osc]] – CutA – rat<br />
-[[1xk8]] – CutA – human<br />
-[[2zom]] - CutA - rice<br />
-[[1j2v]] – PhCutA – ''Pyrococcus horikoshii''<br />
-[[3gsd]] - CutA – ''Yersinia pestis''<br />
-[[3opk]] - CutA – ''Salmonella enterica''<br />
-[[2e66]] - PhCutA (mutant)
-===CutA1 binary complex===
-[[1uku]], [[1v99]] – PhCutA + Cu<br />
+== References ==
-[[1v9b]] - PhCutA + Co<br />
+<references/>
-[[1umj]] - PhCutA + guanidine
+[[Category:Topic Page]]