4eu2: Difference between revisions
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The | ==Crystal structure of 20s proteasome with novel inhibitor K-7174== | ||
<StructureSection load='4eu2' size='340' side='right'caption='[[4eu2]], [[Resolution|resolution]] 2.51Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4eu2]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EU2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.509Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WPI:1,4-BIS[(4E)-5-(3,4,5-TRIMETHOXYPHENYL)PENT-4-EN-1-YL]-1,4-DIAZEPANE'>WPI</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eu2 OCA], [https://pdbe.org/4eu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eu2 RCSB], [https://www.ebi.ac.uk/pdbsum/4eu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eu2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PSA1_YEAST PSA1_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. | |||
==See Also== | |||
*[[Proteasome 3D structures|Proteasome 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae S288C]] | |||
[[Category: Akutsu M]] | |||
[[Category: Furukawa Y]] | |||
[[Category: Izumi T]] | |||
[[Category: Kano Y]] | |||
[[Category: Kikuchi J]] | |||
[[Category: Nobuyoshi M]] | |||
[[Category: Ohki M]] | |||
[[Category: Park S-Y]] | |||
[[Category: Shibayama N]] | |||
[[Category: Sugiyama K]] | |||
[[Category: Wada T]] | |||
[[Category: Yamada S]] | |||
Latest revision as of 08:50, 20 March 2024
Crystal structure of 20s proteasome with novel inhibitor K-7174
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