4gxy: Difference between revisions
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New page: '''Unreleased structure''' The entry 4gxy is ON HOLD Authors: Serganov, A., Peselis, A. Description: RNA structure |
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==RNA structure== | |||
<StructureSection load='4gxy' size='340' side='right'caption='[[4gxy]], [[Resolution|resolution]] 3.05Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4gxy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Symbiobacterium_thermophilum Symbiobacterium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GXY FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCC:CYTIDINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>CCC</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=IRI:IRIDIUM+HEXAMMINE+ION'>IRI</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gxy OCA], [https://pdbe.org/4gxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gxy RCSB], [https://www.ebi.ac.uk/pdbsum/4gxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gxy ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Coenzyme B(12) has a key role in various enzymatic reactions and controls expression of bacterial genes through riboswitches. Here we report the crystal structure of the Symbiobacterium thermophilum B(12) riboswitch bound to its ligand adenosylcobalamin. The riboswitch forms a unique junctional structure with a large ligand-binding pocket tailored for specific recognition of the adenosyl moiety and flanked by structural elements that stabilize the regulatory region and enable control of gene expression. | |||
Structural insights into ligand binding and gene expression control by an adenosylcobalamin riboswitch.,Peselis A, Serganov A Nat Struct Mol Biol. 2012 Nov;19(11):1182-4. doi: 10.1038/nsmb.2405. Epub 2012, Oct 14. PMID:23064646<ref>PMID:23064646</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4gxy" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Riboswitch 3D structures|Riboswitch 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Symbiobacterium thermophilum]] | |||
[[Category: Peselis A]] | |||
[[Category: Serganov A]] | |||
