2kj3: Difference between revisions

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[[Image:2kj3.png|left|200px]]


{{STRUCTURE_2kj3|  PDB=2kj3  |  SCENE=  }}
==High-resolution structure of the HET-s(218-289) prion in its amyloid form obtained by solid-state NMR==
 
<StructureSection load='2kj3' size='340' side='right'caption='[[2kj3]]' scene=''>
===High-resolution structure of the HET-s(218-289) prion in its amyloid form obtained by solid-state NMR===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2kj3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Podospora_anserina Podospora anserina]. The September 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Amyloids''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_9 10.2210/rcsb_pdb/mom_2015_9]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KJ3 FirstGlance]. <br>
{{ABSTRACT_PUBMED_20828131}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kj3 OCA], [https://pdbe.org/2kj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kj3 RCSB], [https://www.ebi.ac.uk/pdbsum/2kj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kj3 ProSAT]</span></td></tr>
==About this Structure==
</table>
[[2kj3]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Podospora_anserina Podospora anserina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJ3 OCA].  
== Function ==
[https://www.uniprot.org/uniprot/HETS_PODAS HETS_PODAS] Responsible for heterokaryon incompatibility, a process that ensures that during spontaneous, vegetative cell fusion only compatible cells from the same colony survive (non-self-recognition). Forms a prion for the non-Mendelian trait [het-s]. Interacts with het-S from incompatible cells to trigger a lethal reaction that prevents the formation of viable heterokaryons. It is unknown if the native, soluble protein has a cellular function.<ref>PMID:1886611</ref> <ref>PMID:8224826</ref> <ref>PMID:9275200</ref>


==See Also==
==See Also==
*[[Prion|Prion]]
*[[Prion 3D structures|Prion 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:020828131</ref><ref group="xtra">PMID:018339938</ref><ref group="xtra">PMID:019504509</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Amyloids]]
[[Category: Large Structures]]
[[Category: Podospora anserina]]
[[Category: Podospora anserina]]
[[Category: Ab, E.]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Lange, A.]]
[[Category: AB E]]
[[Category: Loquet, A.]]
[[Category: Lange A]]
[[Category: Meier, B H.]]
[[Category: Loquet A]]
[[Category: Melckebeke, H Van.]]
[[Category: Meier BH]]
[[Category: Wasmer, C.]]
[[Category: Van Melckebeke H]]
[[Category: Amyloid fibril]]
[[Category: Wasmer C]]
[[Category: Asparagine ladder]]
[[Category: Beta-helix]]
[[Category: Beta-solenoid]]
[[Category: Hydrophobic core]]
[[Category: Parallel beta-sheet]]
[[Category: Prion]]
[[Category: Protein fibril]]
[[Category: Salt bridge]]
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