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[[Image:1s8h.png|left|200px]]


{{STRUCTURE_1s8h|  PDB=1s8h  |  SCENE=  }}
==Crystal structure of Lys49-Phospholipase A2 from Agkistrodon contortrix laticinctus, first fatty acid free form==
 
<StructureSection load='1s8h' size='340' side='right'caption='[[1s8h]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
===Crystal structure of Lys49-Phospholipase A2 from Agkistrodon contortrix laticinctus, first fatty acid free form===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1s8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Agkistrodon_contortrix_laticinctus Agkistrodon contortrix laticinctus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S8H FirstGlance]. <br>
{{ABSTRACT_PUBMED_15596433}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s8h OCA], [https://pdbe.org/1s8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s8h RCSB], [https://www.ebi.ac.uk/pdbsum/1s8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s8h ProSAT]</span></td></tr>
[[1s8h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Agkistrodon_contortrix_laticinctus Agkistrodon contortrix laticinctus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S8H OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/PA2H1_AGKCL PA2H1_AGKCL] Snake venom phospholipase A2 homolog that has myotoxic activities. Lacks enzymatic activity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s8/1s8h_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s8h ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Phospholipase A2|Phospholipase A2]]
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
 
*[[Phospholipase A2 homolog|Phospholipase A2 homolog]]
==Reference==
__TOC__
<ref group="xtra">PMID:015596433</ref><references group="xtra"/>
</StructureSection>
[[Category: Agkistrodon contortrix laticinctus]]
[[Category: Agkistrodon contortrix laticinctus]]
[[Category: Ambrosio, A L.B.]]
[[Category: Large Structures]]
[[Category: Araujo, H S.Selistre de.]]
[[Category: Ambrosio ALB]]
[[Category: Garratt, R C.]]
[[Category: Garratt RC]]
[[Category: Nonato, M C.]]
[[Category: Nonato MC]]
[[Category: Ownby, C L.]]
[[Category: Ownby CL]]
[[Category: Souza, D H.F de.]]
[[Category: Selistre de Araujo HS]]
[[Category: Fatty acid free form]]
[[Category: De Souza DHF]]
[[Category: Hydrolase]]
[[Category: Lys49-phospholipase a2]]
[[Category: Myotoxicity]]
[[Category: Snake venom]]
[[Category: Toxin]]

Latest revision as of 08:29, 1 May 2024

Crystal structure of Lys49-Phospholipase A2 from Agkistrodon contortrix laticinctus, first fatty acid free form

1s8h, resolution 1.80Å

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