Sphingomyelinase: Difference between revisions
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<StructureSection load='1zwx' size='350' side='right' caption='Sphingomyelinase complex with glycerol and phosphate ion (PDB entry [[21zwx])' scene=''> | |||
== Function == | |||
'''Sphingomyelinase''' (SMase) or '''sphingomyelin phosphodiesterase''' is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and [[Ceramide]]<ref>PMID:11001563</ref>. The SMase is classified into 5 types according to their pH dependence and cation dependence. | |||
*'''Acid SMase-like phosphodiesterase''' is a paralog of '''acid SMase''' and thus though related by gene duplication has different functions. | |||
*'''Acid SMase-like phosphodiesterase 3A''' hydrolyzes nucleotides triphosphates and diphosphates. | |||
*'''Acid SMase-like phosphodiesterase 3B''' is a GPI-anchored protein with role in inflammatory processes and kidney disease<ref>PMID:27687724</ref>. | |||
*'''Alkaline SMase''' hydrolyses sphingomyelin in the intestinal tract and bile<ref>PMID:16631405</ref>. | |||
See also [[Lipid signaling]]. | |||
== Disease == | |||
Mutations in acid SMase are found in patients with Niemann-Pick disease<ref>PMID:17011332</ref>. | |||
</StructureSection> | |||
==3D structures of sphingomyelinase== | ==3D structures of sphingomyelinase== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*SMase | |||
[[3rlh]], [[3rlg]] – SMase D (mutant) – ''Loxosceles intermedia''<br /> | **[[5uvg]] – hSMase catalytic domain – human<br /> | ||
[[1xx1]], [[2f9r]] – SMase I – ''Loxosceles laeta''<br /> | **[[3rlh]], [[3rlg]] – SMase D (mutant) – ''Loxosceles intermedia''<br /> | ||
[[1zwx]] – SMase C – ''Listeria ivanovii''<br /> | **[[1xx1]], [[2f9r]] – SMase I – ''Loxosceles laeta''<br /> | ||
[[2ddr]], [[2dds]], [[2ddt]] – BcSMase + cation – ''Bacillus cereus''<br /> | **[[1zwx]] – SMase C – ''Listeria ivanovii''<br /> | ||
[[2uyr]] – BcSMase (mutant) | **[[2ddr]], [[2dds]], [[2ddt]] – BcSMase + cation – ''Bacillus cereus''<br /> | ||
**[[2uyr]] – BcSMase (mutant)<br /> | |||
**[[7cne]] – SMase C – ''Streptomyces griseocarneus''<br /> | |||
*Acid SMase | |||
**[[5jg8]], [[5i81]], [[5i8r]] – hSMase <br /> | |||
**[[5i85]] – hSMase + phosphocholine<br /> | |||
**[[5fib]] – mSMase – mouse<br /> | |||
**[[5hqn]] – mSMase catalytic domain<br /> | |||
**[[5fi9]] – mSMase + inhibitor<br /> | |||
**[[5fic]] – mSMase + lipid<br /> | |||
*Acid SMase-like phosphodiesterase | |||
**[[5ebb]] – hSMase 3A<br /> | |||
**[[5ebe]] – hSMase 3A + CMP<br /> | |||
**[[5fc1]], [[5fc7]], [[5fca]] – mSMase 3A<br /> | |||
**[[5fcb]] – mSMase 3A + AMP<br /> | |||
**[[5fc6]] – mSMase 3A + AMPCP<br /> | |||
**[[5fc5]] – mSMase 3A + phosphocholine<br /> | |||
**[[5kar]] – mSMase 3B<br /> | |||
**[[5kas]] – mSMase 3B + phosphocholine<br /> | |||
*Alkaline SMase | |||
**[[5udy]] – hSMase <br /> | |||
**[[5tcd]] – hSMase + phosphocholine<br /> | |||
}} | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
