4hym: Difference between revisions
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New page: '''Unreleased structure''' The entry 4hym is ON HOLD Authors: Bensen, D.C., Creighton, C.J., Kwan, B., Tari, L.W. Description: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisom... |
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==Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.== | |||
<StructureSection load='4hym' size='340' side='right'caption='[[4hym]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4hym]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._holarctica_LVS Francisella tularensis subsp. holarctica LVS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HYM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CJC:7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)PYRIDO[2,3-B]PYRAZIN-2(1H)-ONE'>CJC</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hym OCA], [https://pdbe.org/4hym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hym RCSB], [https://www.ebi.ac.uk/pdbsum/4hym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hym ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PARE_FRATH PARE_FRATH] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA (PubMed:23352267, PubMed:23294697, PubMed:24386374). Performs the decatenation events required during the replication of a circular DNA molecule.[HAMAP-Rule:MF_00938]<ref>PMID:23352267</ref> <ref>PMID:24386374</ref> <ref>PMID:23294697</ref> | |||
==See Also== | |||
*[[Topoisomerase 3D structures|Topoisomerase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Francisella tularensis subsp. holarctica LVS]] | |||
[[Category: Large Structures]] | |||
[[Category: Bensen DC]] | |||
[[Category: Creighton CJ]] | |||
[[Category: Kwan B]] | |||
[[Category: Tari LW]] | |||
Latest revision as of 11:48, 1 March 2024
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
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