Topoisomerase 3D structures

3D Structures of Topoisomerase

Updated on 28-December-2023 - For a general description of the protein see Topoisomerase

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• Topoisomerase I (ATP-independent)
  • 1tl8, 1sc7 – hTOPI+DNA+indenoisoquinoline – human
    
  • 1seu - hTOPI+DNA+indolocarbazole
    
  • 1t8i, 1rr8, 1rrj - hTOPI+DNA+camptothesin
    
  • 1r49 – hTOPI (mutant)
    
  • 1mw8 – hTOPI (mutant) N-terminal+DNA
    
  • 1mw9 - hTOPI (mutant) N-terminal
    
  • 1nh3 – hTOPI C-terminal+DNA+Ara-C
    
  • 1k4s, 1lpq, 1ej9, 1a31, 1a35, 1a36 – hTOPI+DNA
    
  • 1k4t - hTOPI+DNA+topotecan
    
  • 1ois – yTOPI N-terminal - yeast
    
  • 1cy0, 4rul – EcTOPI+DNA - Escherichia coli
    
  • 3px7 – EcTOPI (mutant) +DNA
    
  • 1cy2, 1cy1 – EcTOPI+5’TPTPTP3’
    
  • 1cy6, 1cy7, 1cy8 – EcIOPI+TMP
    
  • 1cy9, 1cyy – EcTOPI domain II+III
    
  • 1yua – EcTOPI C-terminal
    
  • 1ecl, 1cy4 - EcTOPI N-terminal
    
  • 3pwt - EcTOPIA N-terminal (mutant)
    
  • 1a41 – VvTOPI C-terminal – Vaccinia virus
    
  • 1vcc – VvTOPI N-terminal
    
  • 5d5h, 5uj1, 5ujy, 8tfg - MtTOPI – Mycobacterium tuberculosis
    
  • 6cq2, 6cqi, 8czq – MtTOPI + DNA
    
  • 3igc, 2h7f, 2h7g – TOPI+DNA – Smallpox virus
    
  • 2gai, 2gaj – TOPI – Thermotoga maritime
    
  • 2f4q – TOPIB – Deinococcus radiodurans
    
  • 6ozw – TOPI N terminal – Streptococcus mutans
    
  • 6pcm – TOPI + DNA – Mycolicibacterium smegmatis
    
  • 6z01, 6z03 – TOPI – Candidatus caldarcheum subterraneum
    
  • 8sjh, 8sji – TOPI - synthetic
    
• Topoisomerase I (ATP-dependent) is reverse gyrase. See Gyrase
• Topoisomerase II
  • 7l6s – TOPII ATPase and transducer domain 103-525 - baboon
    
  • 6ca8 – TOPII DNA-binding domain 469-1212 – Plasmodium falciparum
    
  • 8j9y, 8j9z – TOPII – African swine fever virus – Cryo EM
    
• Topoisomerase IIA
  • 1zxm – hTOPIIA+AMP-PNP
    
  • 1zxn, 4r1f - hTOPIIA+ADP
    
  • 4fm9 - hTOPIIA+DNA
    
  • 5gwk - hTOPIIA+DNA + drug
    
  • 6zy5, 6zy6, 6zy7, 6zy8 - hTOPIIA+DNA + AMPPNP – Cryo EM
    
  • 3l4j – yTOPII apo+DNA
    
  • 3l4k - yTOPII+DNA+Zn
    
  • 2rgr - yTOPIIA+DNA
    
  • 4gfh - yTOPIIA+DNA + ANPPNP
    
  • 1qzr – yTOPII N-terminal+dexrazoxane
    
  • 1pvg – yTOPII N-terminal
    
  • 1bjt, 1bgw – yTOPII core
    
  • 8gcc – TOPIIA + DNA + inhibitor – Trypanosoma cruzi – Cryo EM
    
• Topoisomerase IIB topo VI
  • 4j3n - hTOPIIB subunit A+B + DNA
    
  • 5zrf, 5zen, 5zqf - hTOPIIB subunit B + DNA
    
  • 4g0w, 3qx3, 4g0v, 4g0u, 5gwj, 5gwi - hTOPIIB + DNA + anti-cancer drug
    
  • 7qfn - hTOPIIB ATPase domain 50-449 + ADP
    
  • 7qfo - hTOPIIB ATPase domain + AMPPNP
    
  • 7zbg - hTOPIIB ATPase domain + ADP + piperazine derivative
    
  • 2zbk – SsTOPIIB subunit A+B – Sulfolobus shibatae
    
  • 2hkj, 1mu5, 1mx0 - SsTOPIIB subunit B
    
  • 1z59, 1z5a - SsTOPIIB subunit B+ADP
    
  • 1z5b - SsTOPIIB subunit B+ADP+AlF4
    
  • 1z5c - SsTOPIIB subunit B+ADP+Pi
    
  • 2q2e - TOPIIB subunit A+B – Methanosarcina mazei
    
  • 1d3y - TOPIIB subunit A - Methanocaldococcus janaschii
    
• Topoisomerase III
  • 4cgy, 4cht – hTOPIIIα + RecQ-mediated genome instability protein
    
  • 5gvc – hTOPIIIβ topo domain
    
  • 5gve – hTOPIIIβ topo domain + Tudor domain-containing protein
    
  • 2o19, 2o54, 2o59, 2o5c, 2o5e, 1i7d – EcTOPIII+DNA
    
  • 1d6m - EcTOPIII
    
  • 6k8n – SsTOPIII – Sulfolobus solfataricus
    
  • 6k8o – SsTOPIII + DNA
    
• Topoisomerase IV
  • 3fv5 – EcTOPIV ParE subunit
    
  • 1zvt, 1zvu - EcTOPIV ParC subunit
    
  • 1s14 – EcTOPIV ParE subunit
    
  • 2nov - SpTOPIV ParC subunit
    
  • 2inr - SaTOPIV ParC subunit
    
  • 1wp5 – TOPIV C-terminal – Geobacillus stearothermophilus<br />
  • 2xkj – AbTOPIV ParE+ParC subunits – Acinetobacter baumannii
    
  • 3lnu, 3lps - XoTOPIV ParE subunit N-terminal – Xanthomonas oryzae
    
  • 6bq9 - TOPIV ParC NTD – Pseudomonas putida
    
• Topoisomerase IV complexes
  • 4hxz, 4hy1 - hTOPIV ParE subunit + inhibitor
    
  • 4hz0 - EcTOPIV ParE subunit + inhibitor
    
  • 4mn4 - EcTOPIV ParC subunit + MukB
    
  • 1s16 - EcTOPIV ParE subunit +ADPNP
    
  • 3ksb, 4i3h, 2ksb - SpTOPIV ParE + ParC subunits +DNA - Streptococcus pneumoniae
    
  • 4juo, 4koe, 3rae, 3rad, 3k9f - SpTOPIV ParE + ParC subunits +DNA + floxacin derivative
    
  • 4kpe, 3foe, 3fof, 4kpf - SpTOPIV ParE + ParC subunits (mutant) +DNA + quinolone derivative
    
  • 3raf, 3ltn - SpTOPIV ParE + ParC subunits +DNA+quinazoline derivative
    
  • 4z53, 4z4q, 4z3o - SpTOPIV ParE + ParC subunits +DNA+ drug
    
  • 4em7, 4emv, 4lp0, 4lpb, 4mb9, 4mbc, 4mot, 5boc, 5bod, 5yig - SpTOPIV ParE subunit + inhibitor
    
  • 5j5q, 5j5p - SpTOPIV ParE subunit + DNA
    
  • 4url, 4urn - SaTOPIV ParE subunit N terminal + antibiotic
    
  • 2xkk - AbTOPIV ParE + ParC subunits +DNA
    
  • 4hym, 4kqv - TOPIV ParE subunit + inhibitor – Francisella tularensis
    
  • 4hz5 - TOPIV ParE subunit + inhibitor – Enterococcus faecalis
    
  • 5eix - KpTOPIV ParE subunit + DNA + levofloxacin – Klebsiella pneumoniae
    
  • 6waa, 7lhz - KpTOPIV ParE CTD + ParC NTD + DNA + inhibitor
    
  • 7cmp - XoTOPIV ParE subunit + AMPPNP
    
• Topoisomerase V
  • 2csb, 2csd – MkTOPV 1-519 – Methanopyrus kandleri
    
  • 5hm5 - MkTOPV 1-854
    
  • 4gfj – MkTOPV 1-685
    
  • 3m6k – MkTOPV 1-380
    
  • 3m7g – MkTOPV 1-269
    
  • 3m6z - MkTOPV 1-380 +guanidine
    
  • 3m7d - MkTOPV 1-380 +dioxane
    
  • 3m6z, 8df7, 8df8, 8df9, 8dfb - MkTOPV (mutant) 1-854 + DNA
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel