4iim: Difference between revisions
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==Crystal structure of the Second SH3 Domain of ITSN1 bound with a synthetic peptide== | |||
<StructureSection load='4iim' size='340' side='right'caption='[[4iim]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4iim]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IIM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iim OCA], [https://pdbe.org/4iim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iim RCSB], [https://www.ebi.ac.uk/pdbsum/4iim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iim ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref> | |||
==See Also== | |||
*[[Intersectin|Intersectin]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Dong A]] | |||
[[Category: Edwards AM]] | |||
[[Category: Gu J]] | |||
[[Category: Guan X]] | |||
[[Category: Huang H]] | |||
[[Category: Sidhu S]] | |||
[[Category: Tong Y]] | |||
[[Category: Wernimont A]] | |||
Latest revision as of 15:23, 20 September 2023
Crystal structure of the Second SH3 Domain of ITSN1 bound with a synthetic peptide
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