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[[Image:1tip.png|left|200px]]


{{STRUCTURE_1tip| PDB=1tip | SCENE= }}
==THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE==
<StructureSection load='1tip' size='340' side='right'caption='[[1tip]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1tip]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TIP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=NEP:N1-PHOSPHONOHISTIDINE'>NEP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tip OCA], [https://pdbe.org/1tip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tip RCSB], [https://www.ebi.ac.uk/pdbsum/1tip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tip ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/F261_RAT F261_RAT] Synthesis and degradation of fructose 2,6-bisphosphate.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ti/1tip_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tip ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of the fructose-2,6-bisphosphatase domain trapped during the reaction reveal a phosphorylated His 258, and a water molecule immobilized by the product, fructose-6-phosphate. The geometry suggests that the dephosphorylation step requires prior removal of the product for an 'associative in-line' phosphoryl transfer to the catalytic water.


===THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE===
Crystal structure of a trapped phosphoenzyme during a catalytic reaction.,Lee YH, Olson TW, Ogata CM, Levitt DG, Banaszak LJ, Lange AJ Nat Struct Biol. 1997 Aug;4(8):615-8. PMID:9253407<ref>PMID:9253407</ref>


{{ABSTRACT_PUBMED_9253407}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 1tip" style="background-color:#fffaf0;"></div>
[[1tip]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TIP OCA].
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:009253407</ref><references group="xtra"/>
</StructureSection>
[[Category: Fructose-2,6-bisphosphate 2-phosphatase]]
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Banaszak, L J.]]
[[Category: Banaszak LJ]]
[[Category: Lange, A J.]]
[[Category: Lange AJ]]
[[Category: Lee, Y H.]]
[[Category: Lee Y-H]]
[[Category: Levitt, D G.]]
[[Category: Levitt DG]]
[[Category: Ogata, C M.]]
[[Category: Ogata CM]]
[[Category: Olson, T W.]]
[[Category: Olson TW]]
[[Category: Atp-binding]]
[[Category: Hydrolase]]
[[Category: Kinase]]
[[Category: Multifunctional enzyme]]
[[Category: Multigene family]]
[[Category: Phosphorylation]]
[[Category: Transferase]]

Latest revision as of 22:15, 26 March 2025

THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE

1tip, resolution 2.20Å

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