2kpz: Difference between revisions
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==Human NEDD4 3RD WW Domain Complex with The Human T-cell Leukemia virus 1 GAG-Pro poliprotein Derived Peptide SDPQIPPPYVEP== | |||
<StructureSection load='2kpz' size='340' side='right'caption='[[2kpz]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2kpz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/HTLV-1_isolate_Mel_15 HTLV-1 isolate Mel 15] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KPZ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kpz OCA], [https://pdbe.org/2kpz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kpz RCSB], [https://www.ebi.ac.uk/pdbsum/2kpz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kpz ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NEDD4_HUMAN NEDD4_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2.<ref>PMID:17218260</ref> <ref>PMID:18562292</ref> <ref>PMID:20086093</ref> <ref>PMID:21765395</ref> <ref>PMID:21399620</ref> | |||
== | ==See Also== | ||
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] | |||
== References == | |||
== | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: HTLV-1 isolate Mel 15]] | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Blanco | [[Category: Large Structures]] | ||
[[Category: Bonet | [[Category: Blanco FJ]] | ||
[[Category: Cobos | [[Category: Bonet R]] | ||
[[Category: Iglesias-Bexiga | [[Category: Cobos ES]] | ||
[[Category: Luque | [[Category: Iglesias-Bexiga M]] | ||
[[Category: Macias | [[Category: Luque I]] | ||
[[Category: Macias M]] | |||
Latest revision as of 10:28, 6 September 2023
Human NEDD4 3RD WW Domain Complex with The Human T-cell Leukemia virus 1 GAG-Pro poliprotein Derived Peptide SDPQIPPPYVEP
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