2wcn: Difference between revisions
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==Solution structure of an LNA-modified quadruplex== | |||
<StructureSection load='2wcn' size='340' side='right'caption='[[2wcn]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2wcn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sterkiella_nova Sterkiella nova]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WCN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LCG:[(1R,3R,4R,7S)-7-HYDROXY-3-(GUANIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wcn OCA], [https://pdbe.org/2wcn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wcn RCSB], [https://www.ebi.ac.uk/pdbsum/2wcn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wcn ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Sharp curves: The structure of a locked nucleic acid modified telomeric sequence from Oxytricha nova displays a remarkable folding topology, distinct from the native O. nova quadruplex. Each guanine stretch folds back in a V-shaped turn that puts the first and fourth guanines in the same tetrad, looping over a tetrad with a sharp turn in the DNA backbone, showing how subtle interplay between sequence and conformation defines the folding topology. | |||
Solution structure of a locked nucleic acid modified quadruplex: introducing the V4 folding topology.,Nielsen JT, Arar K, Petersen M Angew Chem Int Ed Engl. 2009;48(17):3099-103. PMID:19308940<ref>PMID:19308940</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2wcn" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
= | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Sterkiella nova]] | |||
[[Category: | [[Category: Arar K]] | ||
[[Category: | [[Category: Nielsen JT]] | ||
[[Category: | [[Category: Petersen M]] | ||
[[Category: | |||
[[Category: | |||
Latest revision as of 12:38, 10 January 2024
Solution structure of an LNA-modified quadruplex
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