4gfn: Difference between revisions

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[[Image:4gfn.jpg|left|200px]]


{{STRUCTURE_4gfn| PDB=4gfn | SCENE= }}
==Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic==
<StructureSection load='4gfn' size='340' side='right'caption='[[4gfn]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4gfn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GFN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SUY:(1R,5S,6S)-3-[5-CHLORO-6-ETHYL-2-(PYRIMIDIN-5-YLSULFANYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL]-3-AZABICYCLO[3.1.0]HEXAN-6-AMINE'>SUY</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gfn OCA], [https://pdbe.org/4gfn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gfn RCSB], [https://www.ebi.ac.uk/pdbsum/4gfn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gfn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GYRB_ENTFA GYRB_ENTFA]


===Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic===
==See Also==
 
*[[Gyrase 3D Structures|Gyrase 3D Structures]]
{{ABSTRACT_PUBMED_23352267}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Enterococcus faecalis V583]]
[[4gfn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis_v583 Enterococcus faecalis v583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GFN OCA].
[[Category: Large Structures]]
[[Category: Enterococcus faecalis v583]]
[[Category: Bensen DC]]
[[Category: Bensen, D C.]]
[[Category: Tari LW]]
[[Category: Tari, L W.]]
[[Category: Trzoss M]]
[[Category: Trzoss, M.]]
[[Category: Atp-binding]]
[[Category: Atp-binding domain]]
[[Category: Cytosol]]
[[Category: Dna gyrase negatively supercoils closed circular double-stranded dna in an atp-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded dna ring]]
[[Category: Isomerase-isomerase inhibitor complex]]
[[Category: Nucleotide-binding]]
[[Category: Topoisomerase]]

Latest revision as of 11:28, 1 March 2024

Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic

4gfn, resolution 1.90Å

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