Gyrase 3D Structures

3D Structure of Gyrase

Updated on 07-August-2025

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• Gyrase Subunit A; Domains – N-terminal 1-523; C-terminal 535-841
  • 3l6v – GyrA C-terminal – Xanthomonas campestris
    
  • 1ajb, 2y3p, 4ckl – EcGyrA N-terminal + drug – Escherichia coli
    
  • 4ckk - EcGyrA N-terminal
    
  • 1zi0, 1ab4 - EcGyrA C-terminal
    
  • 1x75 – EcGyrA14+CcdB
    
  • 4elz - GyrA fragment+CcdB – Vibrio fischeri
    
  • 3ilw, 3ifz - MtGyrA N-terminal – Mycobacterium tuberculosis
    
  • 3uc1, 4g3n - MtGyrA C-terminal
    
  • 1suu - GyrA C-terminal – Borrelia burgdorferi
    
  • 3no0 - GyrA C-terminal – Aquifex aeolicus
    
  • 3lpx – GyrA N-terminal – Colwellia psychrerithraea
    
  • 4ely – GyrA residues 363-497 + CcdB – Shigella flexneri
    
  • 4ddq – GyrA N-terminal – Bacillus subtilis
    
  • 6n1r, 6n1q – SpGyrA N-terminal – Streptococcus pneumoniae – Cryo EM
    
  • 6n1p – SpGyrA N-terminal + DNA – Cryo EM
    
  • 5ztj - SeGyrA C-terminal – Salmonella enterica
    
  • 8j9t - SeGyrA N-terminal
    
• Gyrase Subunit B; Domains – ATPase or N-terminal 1-220; C-terminal 448-675
  • 3g75, 3g7b, 3g7e, 3ttz, 3u2d, 3u2k, 4p8o, 5cph, 5ctu, 5ctw, 5ctx, 5cty, 6tck, 6ttg – GyrB N-terminal residues 2-234 + inhibitor – Staphylococcus aureus
    
  • 5d6p, 5d6q, 5d7c, 5d7d, 5d7r - SaGyrB N-terminal + ligand
    
  • 5npk, 5npp - SaGyrB residues 410-543 + DNA
    
  • 5mmn, 5mmo, 5mmp - EcGyrB N-terminal + antibacterial
    
  • 4urm, 4uro - SaGyrB N-terminal + antibiotic
    
  • 5zxm - SeGyrB N-terminal (mutant)
    
  • 6j90 - SeGyrB N-terminal + ATP
    
  • 3cwv – GyrB truncated – Myxococcus xanthus
    
  • 4wub, 4wuc, 4wud, 4xtj - EcGyrB N-terminal
    
  • 1kzn, 1ei1, 1aj6 - EcGyrB N-terminal+ antibiotic
    
  • 4duh, 4zvi, 5l3j, 6f8j, 4hyp, 6f86, 5z9q, 5z9p, 5z9b, 5z9e, 5z9f, 5z9l, 5z9m, 5z9n, 5z4o, 5z4h, 6yd9, 7c7n, 7c7o, 7dor, 7dpr, 7dps, 7dqf, 7dqh, 7dqi, 7dqj, 7dql, 7dqm, 7dqs, 7dqu, 7dqw, 7p2m, 7p2n, 7p2w, 7p2x - EcGyrB N-terminal+ inhibitor
    
  • 4prv, 4prx, 4pu9 - EcGyrB N-terminal+ ADP
    
  • 5mmn, 5mmo, 5mmp - EcGyrB N-terminal + antibacterial
    
  • 6f96, 6f94, 6kzv, 6kzx, 6kzz, 6l01 - EcGyrB N-terminal + inhibitor
    
  • 1kij – TtGyrB N-terminal+ antibiotic – Thermus thermophilus
    
  • 6enh, 6eng - TtGyrB ATPase domain + coumarine derivative
    
  • 4b6c - MsGyrB N-terminal – Mycobacterium smegmatis
    
  • 6zt5 - MsGyrB + MfpA
    
  • 6zt3 - MsGyrB + ANP
    
  • 4gee, 4gfn, 4ggl, 4hxw, 4k4o, 4kfg, 4ksg, 4ksh, 4ktn – GyrB N-terminal + inhibitor – Enterococcus faecalis
    
  • 2zjt, 3ig0, 3m4i - MtGyrB C-terminal
    
  • 3zkb, 3zkd - MtGyrB N-terminal + AMPPNP
    
  • 3zm7 - MtGyrB N-terminal + AMPPCP
    
  • 4bae - MtGyrB N-terminal (mutant) + inhibitor
    
  • 6j90 - GyrB N-terminal + ATP – Salmonella typhi
    
  • 6m1j, 6m1s, 7ptf, 7ptg, 8bn6 - GyrB ATPase domain + inhibitor – Pseudomonas aeruginosa
    
  • 6y8l, 6y8n, 6y8o - GyrB ATPase domain + drug – Mycobacterium thermoresistibile
    
  • 7qpl, 7pqm - AbGyrB ATPase domain + inhibitor – Acinetobacter baumannii
    
  • 7pqi - AbGyrB ATPase domain + antibiotic
    
• Gyrase Subunit A+Subunit B
  • 2xco, 2xcq - SaGyrB C-terminal/SaGyrA N-terminal
    
  • 4plb - SaGyrB C-terminal/SaGyrA N-terminal +DNA
    
  • 2xcr, 2xcs, 4bul - SaGyrB C-terminal/SaGyrA N-terminal (mutant)+DNA
    
  • 2xct - SaGyrB C-terminal/SaGyrA N-terminal (mutant) +DNA+ antibiotic
    
  • 4tma - SaGyrB C-terminal- + SaGyrA N-terminal + Gyr inhibitor YACG
    
  • 5cdn, 5cdo, 5cdp, 6fqv, 6z1a – SaGyrA + SaGyrB + DNA
    
  • 6qx2, 6qx1, 6qtp, 6qtk – SaGyrA + SaGyrB + DNA + inhibitor
    
  • 5cdq, 6fqm, 6fqs - SaGyrB + GyrA + DNA + antibiotic
    
  • 5bs3, 5iwi, 5iwm, 6qx2, 6qx1, 6qtp, 6qtk, 9n26, 9n39 - SaGyrB + GyrA + DNA + inhibitor
    
  • 6fm4, 7fvs, 7fvt, 7mvs - SaGyrB (mutant) + GyrA + DNA + inhibitor
    
  • 5cdm – SaGyrA + SaGyrB (mutant) + DNA
    
  • 5cdr, 9fz6 – SaGyrA (mutant) + SaGyrB (mutant) + DNA
    
  • 4z2c, 4z2d - SpGyrB + GyrA + DNA
    
  • 4z2e - SpGyrB + GyrA + DNA + antibiotic
    
  • 6gav, 6gau - MtGyrB + GyrA
    
  • 5bs8, 5bta, 5btd, 5btg, 5btl, 8s7o - MtGyrB + GyrA + DNA + antibiotic
    
  • 5btc, 5btf, 5bti, 5btn - MtGyrB + GyrA (mutant) + DNA + antibiotic
    
  • 9foy - MtGyrB + GyrA + DNA + inhibitor
    
  • 7ugw - MtGyrB + GyrA (mutant) + DNA + inhibitor
    
  • 3nuh – EcGyrA+EcGyrB
  • 6rks, 6rku, 6rkv, 6rkw, 8qdx, 8qqi, 8qqs, 8qqu, 9gbv - EcGyrA + GyrB + DNA – Cryo EM
    
  • 7z9m - EcGyrA + GyrB + DNA + pyridine derivative – Cryo EM
    
  • 7z9c, 7z9g, 7z9k, 8bp2, 9ggq - EcGyrA + GyrB + DNA + antibiotic – Cryo EM
    
• Gyrase
  • 6ca8 – Gyr residues 469-1212 – Plasmodium falciparum
    
• Reverse Gyrase
  • 1gku – AfTop-RG – Archaeoglobus fulgidus
    
  • 1gl9 - AfTop-RG+ADPNP
    
  • 3oiy, 3p4y – TmTop-RG helicase domain – Thermotoga maritima
    
  • 4ddt, 4ddu, 4ddv, 4ddw, 4ddx - TmTop-RG
  • 7fse, 7fsf, 8ofb – TmTop-RG (mutant)

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Michal Harel, Joel L. Sussman