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| [[Image:1nxd.png|left|200px|thumb|Crystal Structure of Concanavalin A, [[1nxd]]]]
| | <StructureSection load='1qdc' size='350' side='right' caption='Concanavalin A complex with trisacchride, Mn+2 (small purple), Cl- (large green) and Ca+2 (small green) ions (large purple) (PDB entry [[1qdc]])' scene='41/415806/Cv/1'> |
| {{STRUCTURE_1nxd| PDB=1nxd | SIZE=400| SCENE=Concanavalin_A/Concanavalin_a/1 |right|CAPTION=Concanavalin A complex with glycerol, azide, Mn+2 and Na+ ions, [[1nxd]] }}
| | __TOC__ |
| | == Function == |
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| | '''Concanavalin A''' (ConA) is a carbohydrate-binding protein from jack-bean (''Canavalia ensiformis''). It binds to certain sugars and to metal. It is used to characterize glycoproteins on cell surfaces.<ref>PMID:9546043</ref>. |
| | *'''Concanavalin B''' (ConB) is related to chitinase with 40% sequence identity.<ref>PMID:7490746</ref>. |
| | *'''Concanavalin BR''' (ConBR) is ConA from Brazilian jack bean. |
| | *'''Concanavalin V''' (ConV) is a D-mannose/D-glucose-binding lectin. |
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| | == Relevance == |
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| | ConA has therapeutic effect on liver cancer. |
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| | == Structural highlights == |
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| | ConA is the <scene name='41/415806/Cv/2'>homotetramer</scene> with D2 symmetry. ConA contains a <scene name='41/415806/Cv/7'>metal - Mn+2 and Ca+2 - binding site</scene> as well as a <scene name='41/415806/Cv/8'>sugar binding site</scene>. |
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| | == 3D Structures of Concanavalin == |
| | [[Concanavalin 3D structures]] |
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| | </StructureSection> |
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| | | == References == |
| | | <references/> |
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| '''Concanavalin A''' (ConA) is a carbohydrate-binding protein from jack-bean ( ''Canavalia ensiformis''). It binds to certain sugars and to metal. It is used to characterize glycoproteins on cell surfaces.
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| {{TOC limit|limit=2}}
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| == 3D Structures of Concanavalin A ==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| [[2uu8]], [[1nxd]], [[1gkb]], [[3enr]], [[1qny]], [[1vln]], [[1jbc]], [[1cnv]], [[2cna]], [[3cna]], [[3nwk]] – CeConA – ''Canavalia ensiformis''<br />
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| [[2yz4]], [[1xqn]], [[1c57]] – CeConA – neutron<br />
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| [[2ctv]] – CeConA – Laue<br />
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| [[1cn1]], [[1apn]], [[1dq0]], [[1dq2]] – CeConA demetallized<br />
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| [[2g4i]], [[2a7a]] – ConA – ''Canavalia virosa''<br />
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| [[1wuv]] – CgConA – ''Canavalia gladiata''<br />
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| [[3ju9]], [[1azd]] – BrConBR – Brazilian jack-bean<br />
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| [[2cwm]] - CmConA – ''Canavalia maritima''
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| ===Concanavalin binary complex=== | |
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| [[1dq1]], [[1dq5]], [[1dq6]], [[1qgl]], [[1nls]], [[1scr]], [[1scs]] – CeConA + ion<br />
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| [[1enq]], [[1enr]], [[1ens]], [[1con]], [[1dq4]], [[2enr]], [[1ces]] - CeConA demetallized + ion<br />
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| [[3d4k]] – CeConA + sugar analog<br />
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| [[1hqw]], [[1jyc]], [[1jyi]], [[1jui]], [[1joj]], [[1jw6]] – CeConA + polypeptide<br />
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| [[1jn2]] – CeConA + porphyrin derivative<br />
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| [[1cjp]], [[1ona]], [[1gic]], [[1val]], [[1vam]], [[5cna]] – CeConA + pyranoside derivative<br />
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| [[1i3h]], [[1qdc]], [[1qdo]], [[1bxh]], [[1tei]], [[1cvn]] – CeConA + glucoside<br />
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| [[2p37]], [[2cy6]], [[2cyf]], [[2ow4]], [[2p34]] – CmConA + glucoside <br />
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| [[2ef6]], [[2d7f]], [[2ovu]], [[2p2k]] - CgConA + glucoside<br />
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| [[3qlq]] - ConA + glucosyl-octasilsesquioxane – ''Canavalia cathartica''<br />
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| [[3snm]] - ClConA + indole-acetate – ''Canavalia lineata''<br />
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| [[4i30]] – ClConA + adenine<br />
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| [[4h55]] - BrConA + glucoside
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |
