4e7r: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(6 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{STRUCTURE_4e7r|  PDB=4e7r  |  SCENE=  }}
===Thrombin in complex with 3-amidinophenylalanine inhibitor===


==About this Structure==
==Thrombin in complex with 3-amidinophenylalanine inhibitor==
[[4e7r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E7R OCA].  
<StructureSection load='4e7r' size='340' side='right'caption='[[4e7r]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4e7r]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E7R FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0NW:3-[(2S)-3-[4-(2-AMINOETHYL)PIPERIDIN-1-YL]-2-{[(2,4-DICHLOROBIPHENYL-3-YL)SULFONYL]AMINO}-3-OXOPROPYL]BENZENECARBOXIMIDAMIDE'>0NW</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e7r OCA], [https://pdbe.org/4e7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e7r RCSB], [https://www.ebi.ac.uk/pdbsum/4e7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e7r ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HIRV2_HIRME HIRV2_HIRME] Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen.


==See Also==
==See Also==
*[[Thrombin|Thrombin]]
*[[Hirudin 3D structures|Hirudin 3D structures]]
*[[Thrombin 3D Structures|Thrombin 3D Structures]]
__TOC__
</StructureSection>
[[Category: Hirudo medicinalis]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Thrombin]]
[[Category: Large Structures]]
[[Category: Heine, A.]]
[[Category: Heine A]]
[[Category: Klebe, G.]]
[[Category: Klebe G]]
[[Category: Ruehmann, E.]]
[[Category: Ruehmann E]]
[[Category: Blood]]
[[Category: Blood clotting]]
[[Category: Blood clotting inhibitor]]
[[Category: Blood coagulation]]
[[Category: Convertion of fibrinogen to fibrin]]
[[Category: Glycosylation]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Kringle]]
[[Category: Serine protease]]
[[Category: Thrombin inhibitor]]
Retrieved from "https://proteopedia.org/4e7r"