1p8d: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (6 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
== | ==X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol== | ||
[[http://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN | <StructureSection load='1p8d' size='340' side='right'caption='[[1p8d]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1p8d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P8D FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO1:17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-OL'>CO1</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p8d OCA], [https://pdbe.org/1p8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p8d RCSB], [https://www.ebi.ac.uk/pdbsum/1p8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p8d ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/1p8d_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p8d ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
[[ | *[[Liver X receptor|Liver X receptor]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bledsoe | [[Category: Large Structures]] | ||
[[Category: Boggs | [[Category: Bledsoe RK]] | ||
[[Category: Collins | [[Category: Boggs S]] | ||
[[Category: Lambert | [[Category: Collins JL]] | ||
[[Category: McKee | [[Category: Lambert MH]] | ||
[[Category: Miller | [[Category: McKee DD]] | ||
[[Category: Moore | [[Category: Miller AB]] | ||
[[Category: Moore | [[Category: Moore J]] | ||
[[Category: Nichols | [[Category: Moore L]] | ||
[[Category: Parks | [[Category: Nichols J]] | ||
[[Category: Watson | [[Category: Parks D]] | ||
[[Category: Williams | [[Category: Watson M]] | ||
[[Category: Willson | [[Category: Williams S]] | ||
[[Category: Wisely | [[Category: Willson TM]] | ||
[[Category: Wisely B]] | |||
Latest revision as of 08:06, 14 February 2024
X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol
| ||||||||||||
