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{{STRUCTURE_3kse|  PDB=3kse  |  SCENE=  }}
===Unreduced cathepsin L in complex with stefin A===


==Disease==
==Unreduced cathepsin L in complex with stefin A==
[[http://www.uniprot.org/uniprot/CYTA_HUMAN CYTA_HUMAN]] Defects in CSTA are the cause of ichthyosis exfoliative autosomal recessive ichthyosis bullosa of Siemens-like (AREI) [MIM:[http://omim.org/entry/607936 607936]]. A form of congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of Siemens and annular epidermolytic ichthyosis. AREI presents shortly after birth as dry, scaly skin over most of the body with coarse peeling of non-erythematous skin on the palms and soles, which is exacerbated by excessive moisture and minor trauma. Electron microscopy analysis of skin biopsies, reveals mostly normal-appearing upper layers of the epidermis, but prominent intercellular edema of the basal and suprabasal cell layers with aggregates of tonofilaments in the basal keratinocytes.<ref>PMID:21944047</ref>  
<StructureSection load='3kse' size='340' side='right'caption='[[3kse]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[3kse]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KSE FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN]] Important for the overall degradation of proteins in lysosomes. [[http://www.uniprot.org/uniprot/CYTA_HUMAN CYTA_HUMAN]] This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.<ref>PMID:21944047</ref>  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kse OCA], [https://pdbe.org/3kse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kse RCSB], [https://www.ebi.ac.uk/pdbsum/3kse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kse ProSAT]</span></td></tr>
[[3kse]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KSE OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes.


==See Also==
==See Also==
*[[Cathepsin|Cathepsin]]
*[[Cathepsin 3D structures|Cathepsin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<references group="xtra"/><references/>
[[Category: Cathepsin L]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Renko, M.]]
[[Category: Large Structures]]
[[Category: Turk, D.]]
[[Category: Renko M]]
[[Category: Cathepsin]]
[[Category: Turk D]]
[[Category: Cystatin]]
[[Category: Cysteine protease]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Lysosome]]
[[Category: Papain-like]]
[[Category: Protease]]
[[Category: Protease-inhibitor complex]]
[[Category: Stefin]]
[[Category: Thiol protease]]
[[Category: Thiol protease inhibitor]]
[[Category: Zymogen]]

Latest revision as of 16:17, 1 November 2023

Unreduced cathepsin L in complex with stefin A

3kse, resolution 1.71Å

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