Cathepsin 3D structures

3D Structures of Cathepsin

Updated on 19-January-2025

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• Procathepsin-A (Lysosomal protective protein)
  • 4ci9, 1ivy, 4mws, 4mwt - hCTSB – human
    
  • 4cia, 4cib - hCTSB + inhibitor
    
• Cathepsin-A
  • 7kdv - hCTSB in Lysosomal Multienzyme Complex – Cryo EM
    
• Procathepsin-B or cysteine peptidase
  • 1pbh, 2pbh, 3pbh – hPCTSB
    
  • 1mir - rPCTSB (mutant) - rat
    
  • 4n4z, 4hwy - TbCTSB – Trypanosoma brucei
    
  • 5fpw, 7e3e, 7e3f, 7e3g – TbCTSB (mutant)
    
• Cathepsin-B mature
  • 2ipp, 1huc – hMCTSB
    
  • 3k9m – hMCTSB+stefin A
    
  • 3ai8 – hMCTSB + antibiotic
    
  • 3cbj, 3cbk – hMCTSB (mutant)+chagasin
    
  • 5mbl, 5mbm – hMCTSB + darpin
    
  • 6ay2, 8b4t, 8he9, 8hei, 8hen – hMCTSB + inhibitor
    
  • 8b5f – hMCTSB + carbamate inhibitor
  • 2dc6, 2dc7, 2dc8, 2dc9, 2dca, 2dcb, 2dcc, 2dcd – bMCTSB+inhibitor – bovine
    
  • 1sp4, 1csb – bMCTSB+epoxysuccinyl inhibitor
    
  • 1ito, 1qdq – bMCTSB +inhibitor
    
  • 1gmy - bMCTSB +dipeptidyl nitrile
    
  • 1the – rMCTSB (mutant)+butanone inhibitor – rat
    
  • 1cpj - rMCTSB (mutant)
    
  • 1cte - rMCTSB+pyrimidine inhibitor
    
  • 3hhi – TbCTSB (mutant) residues 23-340+CA074
    
  • 3mor - TbCTSB residues 23-340
    
• Cathepsin-B1 mature
  • 3qsd, 3s3q, 3s3r - SmCTSB1 (mutant) residues 87-340+ inhibitor – Schistosoma mansoni
    
  • 8c9d, 8cc2, 8ccu - SmCTSB1 + gallinamide inhibitor
  • 6yi7 - SmCTSB1 + azanitrile inhibitor
• Cathepsin-C mature or Dipeptidyl peptidase-I
  • 1k3b – hMCTSC
    
  • 2djf, 2djg, 4oel, 4oem – hMCTSC + dipeptide
    
  • 3pdf, 4cdc, 4cdd, 4cde, 4cdf, 6ic5, 6ic6, 6ic7, 6rn6, 6rn7, 6rn9, 6rni – hMCTSC + inhibitor
    
  • 1jqp – rMCTSC
    
• Cathepsin-D mature
  • 1lyw, 1lya – hMCTSD
    
  • 1lyb - hMCTSD+pepstatin
    
  • 4obz, 4oc6, 4od9 – hMCTSD + non-peptidic inhibitor
    
  • 6qbg, 6qbh, 6qcb – hMCTSD + macrocyclic inhibitor
    
  • 5ux4 – rMCTSD + inhibitor
    
• Cathepsin-E mature
  • 1tzs – hMCTSE+activation peptide from CTSE
    
• Cathepsin-F mature
  • 1m6d – hMCTSF+piperidine inhibitor
    
• Cathepsin-G mature
  • 1kyn – hMCTSG +naphthalene inhibitor
    
  • 1au8, 1cgh - hMCTSG +phosphonate inhibitor
    
  • 1t32 - hMCTSG +piperidine inhibitor
    
  • 6vtm – hMCTSG + MAP domain-containing protein
    
  • 8d4s, 8d4v – hMCTSG + extracellular adherent protein
  • 8d7i, 8d7k, 9asx, 9atk – hMCTSG + extracellular adherent protein + neutrophil elastase
    
  • 8g24, 8g25, 8g26 – hMCTSG + MAP domain-containing protein + neutrophil elastase
    
• Procathepsin-H
  • 6czk – hPCTSH
    
  • 6czs – hPCTSH (mutant)
    
• Cathepsin-H mature
  • 1nb3, 1nb5 – pMCTSH +stefin A – pig
    
  • 8pch - pMCTSH
    
• Procathepsin-K
  • 1by8, 7pck – hPCTSK
    
• Cathepsin-K mature
  • 4n79, 5tun, 4yva, 7pck – hMCTSK
    
  • 5jh3, 5z5o – hMCTSK (mutant)
    
  • 3o1g, 3n3g, 2r6n, 1bgo, 3kwz, 3kx1, 3o0u – hMCTSK+ pyrimidine inhibitor
    
  • 5qby, 5qbv – hMCTSK (mutant) + pyrimidine inhibitor
    
  • 3h7d - hMCTSK (mutant) + chondroitin-4-sulfate
    
  • 3c9e, 4n8w - hMCTSK + chondroitin-4-sulfate
    
  • 3kwb - hMCTSK (mutant)+dioxo-triazine
    
  • 3kw9 - hMCTSK +triazine
    
  • 1yk8 - hMCTSK + cyanamide inhibitor
    
  • 1yt7 - hMCTSK + ketoamide inhibitor
    
  • 4x6j - hMCTSK + benzamide inhibitor
    
  • 2aux, 2auz - hMCTSK + semicarbazone inhibitor
    
  • 1ayu, 1ayv, 1ayw - hMCTSK + carbohydrazide inhibitor
    
  • 2bdl, 1yk7, 1tu6, 1au3, 1au4, 4dmx, 4dmy, 6ql8 - hMCTSK + pyrrolidine inhibitor
    
  • 1snk - hMCTSK + norleucine inhibitor
    
  • 1nl6, 1nlj - hMCTSK+ azepanone inhibitor
    
  • 1q6k, 7qbl - hMCTSK+carbamate inhibitor
    
  • 1au0 - hMCTSK+ diacylaminoethyl ketone inhibitor
    
  • 1au2 - hMCTSK+ propanone inhibitor
    
  • 1atk – hMCTSK+guanidine inhibitor
    
  • 1vsn, 5j94, 4x6h, 4x6i, 6qbs, 6hgy, 6pxf, 6qlx, 6qm0, 7nxl, 7nxm, 7qbm, 7qbn, 7qbo - hMCTSK+ inhibitor
    
  • 6ash – hMCTSK (mutant) + inhibitor
    
  • 2ato – hMCTSK+myocrisin
    
  • 1u9v, 1u9x, 1mem, 6qlm, 6qlw – hMCTSK+piperazine inhibitor
    
  • 1u9w - hMCTSK+imidazole inhibitor
    
  • 5tdi, 4yv8 – hMCTSK + odanacatib
    
  • 5tdi – hMCTSK + lichostatinal
    
  • 5ja7 – hMCTSK (mutant) + effector
    
  • 2ftd – MCTSK+azepan inhibitor – Macaca mulatta
    
  • 2f7d – MCTSK (mutant)+nitrile inhibitor - rabbit
    
  • 5t6u – mMCTSK
    
  • 6bki – mMCTSK (mutant)
    
  • 8v58 - mMCTSK + heparan-sulfate
  • 8v57 – mMCTSK + cystatin-C
    
• Procathepsin-L
  • 1cjl, 1cs8 - hPCTS-L (mutant)
    
  • 7w33, 8gx2 – hPCTS-L + inhibitor
    
  • 7w34 – hPCTS-L (mutant) + inhibitor
    
  • 3qj3 - PCTS-L (mutant) – Tenebrio molitor
    
• Cathepsin-L mature
  • 7z3t – hMCTSL
    
  • 4axl – hMCTSL catalytic domain
    
  • 4axm – hMCTSL catalytic domain + inhibitor
    
  • 1mhw – hMCTSL +tripeptide
    
  • 8uac – hMCTSL + inhibitor
    
  • 7qkb, 7qkc, 7qkd, 7z58, 7zs7, 7zvf, 7zxa, 8a4v, 8a4w, 8a4x, 8a5b, 8ahv, 8b4f, 8c77, 8ofa, 8oza, 8prx, 8qkb – hMCTSL (mutant) + inhibitor
    
  • 1icf – hMCTSL +MHC class II fragment
    
  • 3f75 – MCTSL +CTSL propeptide – Toxoplasma gondii
    
  • 2p86 – TbMCTSL +K11002
    
  • 2nqd - CTSL residues 1-220 (mutant)+chagasin – Trypanosoma cruzi
    
• Procathepsin-L1
  • 2o6x – hPCTSL1 (mutant) – Fasciola hepatica
    
• Cathepsin-L1 mature
  • 4axl – hMCTSL1 catalytic domain
    
  • 3iv2, 5i4h, 6jd0, 6jd8 – hMCTSL1 (mutant)
    
  • 3k24 - hMCTSL1 (mutant) +tripeptide
    
  • 3of8 - hMCTSL1 + dipeptidyl inhibitor
    
  • 2xu1, 2xu3, 2xu4, 2xu5, 2yj2, 2yj8, 2yj9, 2yjb, 2yjc - hMCTSL1 catalytic domain (mutant)+nitrile inhibitor
    
  • 3h89, 3h8b, 3h8c - hMCTSL1 (mutant) + retro-binding inhibitor
    
  • 3hwn, 3hha – hMCTSL1+pyrazole inhibitor
    
  • 5mqy – hMCTSL1 + pyrimidine inhibitor
    
  • 3kse – hMCTSL1 (mutant)+stefin
    
  • 4axm, 5mae, 5maj, 5f02, 3bc3, 3of9 – hMCTSL1 catalytic domain + inhibitor
    
  • 6f06, 6ezx, 6ezp – hMCTSL1 catalytic domain + carboxamide inhibitor
    
• Cathepsin-L2 mature or Cathepsin-V
  • 3h6s – hMCTSL2+clitocypin
    
  • 1fh0 – hMCTSL2 (mutant) +vinyl sulfone inhibitor
    
  • 3kfq - hMCTSL2 (mutant)+stefin
  • 7qgw - hMCTSL2 (mutant) + calpeptin
    
  • 7q8d, 7q8f, 7q8g, 7q8h, 7q8i, 7q8j, 7q8k, 7q8l, 7q8m, 7q8o, 7q8p, 7q8q, 7q9c, 7q9h, 7qff, 7qfh, 7qhj, 7qhk, 7qns, 7qo2 – hMCTSV (mutant) + peptide
• Procathepsin-S
  • 2c0y – hPCTSS (mutant)
    
• Cathepsin-S mature
  • 3n3g, 3n4c - hMCTSS+ pyrimidine inhibitor
    
  • 3ovx - hMCTSS+ aldehyde inhibitor
    
  • 3ovz, 9gj2 - hMCTSS+ ketoamide inhibitor
    
  • 5qc4 – hMCTSS (mutant)+ thioether acetamide
    
  • 3iej, 5qcf, 5qce, 5qcd, 5qcc, 5qcg, 5qch, 5qci - hMCTSS (mutant)+pyrazole inhibitor
    
  • 2h7j, 2hxz- hMCTSS+triazole inhibitor
    
  • 2r9m, 2r9n, 2r9o, 5qcj – hMCTSS+piperidine inhibitor
    
  • 5qbu, 5qbw, 5qbx, 5qbz, 5qc0, 5qc1, 5qc2, 5qc3, 5qc5, 5qc6, 5qc7, 5qc8, 5qc9, 5qca, 5qcb – hMCTSS (mutant) + piperidine inhibitor
    
  • 2op3, 2hhn, 2g7y, 2hh5, 2f1g – hMCTSS+aryl inhibitor
    
  • 2fud, 2fra, 2frq, 2ft2, 1npz, 1nqc, 4p6e, 4p6g, 6yyn, 6yyo, 6yyp, 6yyq, 6yyr, 8rnd – hMCTSS+inhibitor
    
  • 2fye, 2g6d – hMCTSS (mutant)+inhibitor
    
  • 2fq9, 1ms6 – hMCTSS +nitrile inhibitor
    
  • 1glo - hMCTSS (mutant)
    
  • 4bs5, 4mzo, 4mzs - mMCTSS+ pyrrolidine inhibitor
    
  • 4bsq - mMCTSS+ morpholine inhibitor
    
  • 4bpv, 4bqv, 4bs6 - mMCTSS +nitrile inhibitor
    
• Procathepsin-X
  • 1deu - hPCTSX
    
• Cathepsin-X mature
  • 1ef7 – hMCTSX
    

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Michal Harel