2r42: Difference between revisions

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{{STRUCTURE_2r42|  PDB=2r42  |  SCENE=  }}
===The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism===
{{ABSTRACT_PUBMED_18302342}}


==Disease==
==The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism==
[[http://www.uniprot.org/uniprot/KIME_RAT KIME_RAT]] Note=Mutation in the mevalonate kinase gene causes mevalonicaciduria.  
<StructureSection load='2r42' size='340' side='right'caption='[[2r42]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2r42]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R42 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r42 OCA], [https://pdbe.org/2r42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r42 RCSB], [https://www.ebi.ac.uk/pdbsum/2r42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r42 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/KIME_RAT KIME_RAT] Note=Mutation in the mevalonate kinase gene causes mevalonicaciduria.
== Function ==
[https://www.uniprot.org/uniprot/KIME_RAT KIME_RAT] May be a regulatory site in cholesterol biosynthetic pathway.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r42_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r42 ConSurf].
<div style="clear:both"></div>


==Function==
==See Also==
[[http://www.uniprot.org/uniprot/KIME_RAT KIME_RAT]] May be a regulatory site in cholesterol biosynthetic pathway.
*[[Mevalonate kinase|Mevalonate kinase]]
 
__TOC__
==About this Structure==
</StructureSection>
[[2r42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R42 OCA].
[[Category: Large Structures]]
 
==Reference==
<ref group="xtra">PMID:018302342</ref><references group="xtra"/><references/>
[[Category: Mevalonate kinase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Fu, Z.]]
[[Category: Fu Z]]
[[Category: Kim, J P.]]
[[Category: Kim JP]]
[[Category: Miziorko, H M.]]
[[Category: Miziorko HM]]
[[Category: Voynova, N E.]]
[[Category: Voynova NE]]
[[Category: Atp-binding]]
[[Category: Cholesterol biosynthesis]]
[[Category: Farnesyl thiodiphosphate]]
[[Category: Lipid synthesis]]
[[Category: Mevalonate kinase]]
[[Category: Nucleotide-binding]]
[[Category: Peroxisome]]
[[Category: Steroid biosynthesis]]
[[Category: Sterol biosynthesis]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/2r42"