Trichodiene synthase: Difference between revisions
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Michal Harel (talk | contribs) New page: left|200px|thumb|Crystal structure of trichodiene synthase complex with diphosphate and Mg+2 ion [[2q9z]] {{STRUCTURE_2q9z| PDB=2q9z | SIZE=350| SCENE= |right|CAPTION... |
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<StructureSection load='' size='350' side='right' caption='Trichodiene synthase complex with diphosphate, competitive inhibitor and Mg+2 ion (green) [[2q9y]]' scene='54/542259/Cv/1' pspeed='8'> | |||
== Function == | |||
'''Trichodiene synthase''' (TCS) catalyzes the conversion of trans,trans-farnesyl diphosphate to trichodiene and diphosphate (PP). TCS belongs to the family of sesquiterpene syntases which cyclize the acyclic farnesyl diphosphate to a sesquiterpene. TCS contains metal ion-binding motif<ref>PMID:7875326</ref>. | |||
== Structural highlights == | |||
The <scene name='54/542259/Cv/6'>active site</scene> of TCS contains <scene name='54/542259/Cv/7'>diphosphate, the competitive inhibitor benzyl-diethylethanaminium and Mg+2 ions</scene><ref>PMID:17678871</ref>. | |||
</StructureSection> | |||
''' | |||
== 3D Structures of trichodiene synthase == | == 3D Structures of trichodiene synthase == | ||
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[[1yyr]], [[1yys]], [[1yyt]], [[1yyu]], [[2ael]], [[2aet]] – FsTCS (mutant) + PP + Mg + azabisabolene<br /> | [[1yyr]], [[1yys]], [[1yyt]], [[1yyu]], [[2ael]], [[2aet]] – FsTCS (mutant) + PP + Mg + azabisabolene<br /> | ||
[[2q9y]] – FsTCS + PP + Mg + benzyl triethyl ammonium<br /> | [[2q9y]] – FsTCS + PP + Mg + benzyl triethyl ammonium<br /> | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | |||
Latest revision as of 14:02, 26 September 2019
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3D Structures of trichodiene synthase
Updated on 26-September-2019
1jfa – FsTCS – Fusarium sporotrichioides
1kiy, 1yj4, 2ps6 – FsTCS (mutant)
2aek, 2ps4, 2ps7 – FsTCS (mutant) + Mg
1jfg, 2q9z – FsTCS + PP + Mg
1kiz, 1yyq, 2ps5, 2ps8 – FsTCS (mutant) + PP + Mg
1yyr, 1yys, 1yyt, 1yyu, 2ael, 2aet – FsTCS (mutant) + PP + Mg + azabisabolene
2q9y – FsTCS + PP + Mg + benzyl triethyl ammonium
