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{{STRUCTURE_4gec|  PDB=4gec  |  SCENE=  }}
===Crystal Structure of E.coli MenH R124A Mutant===
{{ABSTRACT_PUBMED_23637813}}


==Function==
==Crystal Structure of E.coli MenH R124A Mutant==
[[http://www.uniprot.org/uniprot/MENH_ECOLI MENH_ECOLI]] Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro.<ref>PMID:15808744</ref> <ref>PMID:18284213</ref>
<StructureSection load='4gec' size='340' side='right'caption='[[4gec]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[4gec]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GEC FirstGlance]. <br>
[[4gec]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEC OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gec OCA], [https://pdbe.org/4gec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gec RCSB], [https://www.ebi.ac.uk/pdbsum/4gec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gec ProSAT]</span></td></tr>
<references group="xtra"/><references/>
</table>
[[Category: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase]]
== Function ==
[[Category: Escherichia coli k-12]]
[https://www.uniprot.org/uniprot/MENH_ECOLI MENH_ECOLI] Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro.<ref>PMID:15808744</ref> <ref>PMID:18284213</ref>  
[[Category: Baker, E N.]]
== References ==
[[Category: Guo, Z.]]
<references/>
[[Category: Jiang, M.]]
__TOC__
[[Category: Johnston, J M]]
</StructureSection>
[[Category: 2-succinyl-6-hydroxy-2]]
[[Category: Escherichia coli K-12]]
[[Category: 4-cyclohexadiene-1-carboxylate synthase]]
[[Category: Large Structures]]
[[Category: Alpha beta hydrolase]]
[[Category: Baker EN]]
[[Category: Lyase]]
[[Category: Guo Z]]
[[Category: Menaquinone biosynthesis]]
[[Category: Jiang M]]
[[Category: Menh mutant r124a]]
[[Category: Johnston JM]]
[[Category: Mutant r124a]]
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