2m85: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: '''Unreleased structure''' The entry 2m85 is ON HOLD Authors: Machado, L.E.S.F., Pustovalova, Y., Pozhidaeva, A., Almeida, F.C.L., Bezsonova, I., Korzhnev, D.M. Description: PHD Domain... |
No edit summary |
||
| (8 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==PHD Domain from Human SHPRH== | |||
<StructureSection load='2m85' size='340' side='right'caption='[[2m85]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2m85]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M85 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M85 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m85 OCA], [https://pdbe.org/2m85 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m85 RCSB], [https://www.ebi.ac.uk/pdbsum/2m85 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m85 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SHPRH_HUMAN SHPRH_HUMAN] E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.<ref>PMID:17130289</ref> <ref>PMID:17108083</ref> <ref>PMID:18719106</ref> | |||
==See Also== | |||
*[[Exosome 3D structures|Exosome 3D structures]] | |||
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Almeida FCL]] | |||
[[Category: Bezsonova I]] | |||
[[Category: Korzhnev DM]] | |||
[[Category: Machado LESF]] | |||
[[Category: Pozhidaeva A]] | |||
[[Category: Pustovalova Y]] | |||
Latest revision as of 06:59, 1 May 2024
PHD Domain from Human SHPRH
| ||||||||||||
