4k7r: Difference between revisions
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==Crystal structures of CusC review conformational changes accompanying folding and transmembrane channel formation== | |||
<StructureSection load='4k7r' size='340' side='right'caption='[[4k7r]], [[Resolution|resolution]] 2.09Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4k7r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K7R FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.094Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PK:(2S)-1-(PENTANOYLOXY)PROPAN-2-YL+HEXANOATE'>3PK</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k7r OCA], [https://pdbe.org/4k7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k7r RCSB], [https://www.ebi.ac.uk/pdbsum/4k7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k7r ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CUSC_ECOLI CUSC_ECOLI] Part of a cation efflux system that mediates resistance to copper and silver. In pathogenic strains it allows the bacteria to invade brain microvascular endothelial cells (BMEC) thus allowing it to cross the blood-brain barrier and cause neonatal meningitis.<ref>PMID:11399769</ref> <ref>PMID:12813074</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Bolla JR]] | |||
[[Category: Lei H-T]] | |||
[[Category: Su C-C]] | |||
[[Category: Yu EW]] | |||
Latest revision as of 12:09, 1 March 2024
Crystal structures of CusC review conformational changes accompanying folding and transmembrane channel formation
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