4l9d: Difference between revisions
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==Crystal structure of the PKD1 domain from Vibrio cholerae metalloprotease PrtV== | |||
<StructureSection load='4l9d' size='340' side='right'caption='[[4l9d]], [[Resolution|resolution]] 1.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4l9d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_M66-2 Vibrio cholerae M66-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L9D FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l9d OCA], [https://pdbe.org/4l9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l9d RCSB], [https://www.ebi.ac.uk/pdbsum/4l9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l9d ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PRTV_VIBCM PRTV_VIBCM] Metalloprotease that exhibits a cytotoxic effect leading to cell death. In host tissues, it could play a role in pathogenesis by modulating the stability of the extracellular matrix components such as fibronectin and fibrinogen. Also able to cleave plasminogen.[UniProtKB:Q9KMU6] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Vibrio cholerae M66-2]] | |||
[[Category: Edwin A]] | |||
[[Category: Sauer-Eriksson AE]] | |||
[[Category: Stier G]] | |||
Latest revision as of 12:18, 1 March 2024
Crystal structure of the PKD1 domain from Vibrio cholerae metalloprotease PrtV
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