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{{STRUCTURE_4kbl|  PDB=4kbl  |  SCENE=  }}
===Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism===
{{ABSTRACT_PUBMED_23707686}}


==Function==
==Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism==
[[http://www.uniprot.org/uniprot/ARI1_HUMAN ARI1_HUMAN]] E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of EIF4E2, leading to its subsequent degradation.<ref>PMID:14623119</ref> <ref>PMID:21532592</ref> <ref>PMID:15236971</ref>
<StructureSection load='4kbl' size='340' side='right'caption='[[4kbl]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4kbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KBL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kbl OCA], [https://pdbe.org/4kbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kbl RCSB], [https://www.ebi.ac.uk/pdbsum/4kbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kbl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ARI1_HUMAN ARI1_HUMAN] E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of EIF4E2, leading to its subsequent degradation.<ref>PMID:14623119</ref> <ref>PMID:21532592</ref> <ref>PMID:15236971</ref>  


==About this Structure==
==See Also==
[[4kbl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KBL OCA].
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:023707686</ref><references group="xtra"/><references/>
__TOC__
[[Category: Duda, D M.]]
</StructureSection>
[[Category: Olszewski, J L.]]
[[Category: Homo sapiens]]
[[Category: Schulman, B A.]]
[[Category: Large Structures]]
[[Category: E3 ubiquitin ligase]]
[[Category: Duda DM]]
[[Category: Ligase]]
[[Category: Olszewski JL]]
[[Category: Ring-ibr-ring]]
[[Category: Schulman BA]]

Latest revision as of 12:09, 1 March 2024

Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism

4kbl, resolution 3.30Å

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