4kbb: Difference between revisions
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== | ==Structure of Botulinum neurotoxin B binding domain in complex with both synaptotagmin II and GD1a== | ||
[[http://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO | <StructureSection load='4kbb' size='340' side='right'caption='[[4kbb]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4kbb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KBB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kbb OCA], [https://pdbe.org/4kbb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kbb RCSB], [https://www.ebi.ac.uk/pdbsum/4kbb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kbb ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | |||
== | ==See Also== | ||
[[ | *[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]] | ||
*[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Clostridium botulinum]] | [[Category: Clostridium botulinum]] | ||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Berntsson | [[Category: Berntsson RPA]] | ||
[[Category: Dong | [[Category: Dong M]] | ||
[[Category: Peng | [[Category: Peng L]] | ||
[[Category: Stenmark | [[Category: Stenmark P]] | ||
Latest revision as of 12:09, 1 March 2024
Structure of Botulinum neurotoxin B binding domain in complex with both synaptotagmin II and GD1a
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