2ma6: Difference between revisions
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New page: '''Unreleased structure''' The entry 2ma6 is ON HOLD Authors: Ramelot, T.A., Yang, Y., Janjua, H., Kohan, E., Wang, H., Xiao, R., Acton, T.B., Everett, J.K., Montelione, G.T., Kennedy, ... |
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==Solution NMR Structure of the RING finger domain from the Kip1 ubiquitination-promoting E3 complex protein 1 (KPC1/RNF123) from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8700A== | |||
<StructureSection load='2ma6' size='340' side='right'caption='[[2ma6]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2ma6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MA6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ma6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ma6 OCA], [https://pdbe.org/2ma6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ma6 RCSB], [https://www.ebi.ac.uk/pdbsum/2ma6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ma6 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RN123_HUMAN RN123_HUMAN] Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.<ref>PMID:15531880</ref> <ref>PMID:16227581</ref> | |||
==See Also== | |||
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Acton TB]] | |||
[[Category: Everett JK]] | |||
[[Category: Janjua H]] | |||
[[Category: Kennedy MA]] | |||
[[Category: Kohan E]] | |||
[[Category: Montelione GT]] | |||
[[Category: Ramelot TA]] | |||
[[Category: Wang H]] | |||
[[Category: Xiao R]] | |||
[[Category: Yang Y]] | |||
Latest revision as of 06:59, 1 May 2024
Solution NMR Structure of the RING finger domain from the Kip1 ubiquitination-promoting E3 complex protein 1 (KPC1/RNF123) from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8700A
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