4guq: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (4 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
== | ==Structure of mutS139F p73 DNA binding domain complexed with 20BP DNA response element== | ||
[[http://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN | <StructureSection load='4guq' size='340' side='right'caption='[[4guq]], [[Resolution|resolution]] 3.70Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4guq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GUQ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4guq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4guq OCA], [https://pdbe.org/4guq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4guq RCSB], [https://www.ebi.ac.uk/pdbsum/4guq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4guq ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref> | |||
== | ==See Also== | ||
[[ | *[[P73|P73]] | ||
== References == | |||
== | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Ethayathulla AS]] | ||
[[Category: | [[Category: Nguyen HT]] | ||
[[Category: | [[Category: Viadiu H]] | ||
Latest revision as of 15:56, 14 March 2024
Structure of mutS139F p73 DNA binding domain complexed with 20BP DNA response element
| ||||||||||||
