4gmi: Difference between revisions
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== | ==BACE-1 in complex with HEA-type macrocyclic inhibitor, MV078571== | ||
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN | <StructureSection load='4gmi' size='340' side='right'caption='[[4gmi]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4gmi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GMI FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0XA:(4S,8E)-4-[(1R)-2-{[2-(5-TERT-BUTYL-1,3-OXAZOL-2-YL)PROPAN-2-YL]AMINO}-1-HYDROXYETHYL]-16-METHYL-6-OXA-3-AZABICYCLO[12.3.1]OCTADECA-1(18),8,14,16-TETRAENE-2,13-DIONE'>0XA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmi OCA], [https://pdbe.org/4gmi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gmi RCSB], [https://www.ebi.ac.uk/pdbsum/4gmi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmi ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | |||
== | ==See Also== | ||
[[ | *[[Beta secretase 3D structures|Beta secretase 3D structures]] | ||
== References == | |||
== | <references/> | ||
<references | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Derbyshire | [[Category: Derbyshire D]] | ||
[[Category: Lindberg | [[Category: Lindberg JD]] | ||
Latest revision as of 08:21, 9 October 2024
BACE-1 in complex with HEA-type macrocyclic inhibitor, MV078571
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