4mnb: Difference between revisions
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==Crystal Structure of a complex between the marine anticancer drug Variolin B and DNA== | |||
<StructureSection load='4mnb' size='340' side='right'caption='[[4mnb]], [[Resolution|resolution]] 1.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4mnb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MNB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=VAR:9-AMINO-5-(2-AMINOPYRIMIDIN-4-YL)PYRIDO[3,2 4,5]PYRROLO[1,2-C]PYRIMIDIN-4-OL'>VAR</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mnb OCA], [https://pdbe.org/4mnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mnb RCSB], [https://www.ebi.ac.uk/pdbsum/4mnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mnb ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms. | |||
Intercalative DNA binding of the marine anticancer drug variolin B.,Canals A, Arribas-Bosacoma R, Albericio F, Alvarez M, Aymami J, Coll M Sci Rep. 2017 Jan 4;7:39680. doi: 10.1038/srep39680. PMID:28051169<ref>PMID:28051169</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4mnb" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Albericio F]] | |||
[[Category: Alvarez M]] | |||
[[Category: Arribas-Bosacoma R]] | |||
[[Category: Aymami J]] | |||
[[Category: Canals A]] | |||
[[Category: Coll M]] | |||
