4l7j: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (4 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
== | ==Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE-1)== | ||
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN | <StructureSection load='4l7j' size='340' side='right'caption='[[4l7j]], [[Resolution|resolution]] 1.65Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4l7j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L7J FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.651Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1W2:2-[(3AS,7AR)-2-AMINO-3A-(2,4-DIFLUOROPHENYL)-3A,6,7,7A-TETRAHYDRO[1,3]OXAZOLO[4,5-C]PYRIDIN-5(4H)-YL]PYRIDINE-3-CARBONITRILE'>1W2</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7j OCA], [https://pdbe.org/4l7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l7j RCSB], [https://www.ebi.ac.uk/pdbsum/4l7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7j ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | |||
== | ==See Also== | ||
[[ | *[[Beta secretase 3D structures|Beta secretase 3D structures]] | ||
== References == | |||
== | <references/> | ||
<references | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Dutcher D]] | ||
[[Category: | [[Category: Geck Do MK]] | ||
[[Category: Huestis | [[Category: Huestis MP]] | ||
[[Category: Hunt | [[Category: Hunt KW]] | ||
[[Category: Liu | [[Category: Liu W]] | ||
[[Category: Purkey | [[Category: Purkey HE]] | ||
[[Category: Siu | [[Category: Siu M]] | ||
[[Category: Smith | [[Category: Smith D]] | ||
[[Category: Vigers | [[Category: Vigers G]] | ||
[[Category: Volgraf | [[Category: Volgraf M]] | ||
[[Category: Wang | [[Category: Wang W]] | ||
[[Category: Wu | [[Category: Wu P]] | ||
[[Category: Yu | [[Category: Yu C]] | ||
Latest revision as of 16:14, 20 September 2023
Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE-1)
| ||||||||||||
