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{{STRUCTURE_4m6w|  PDB=4m6w  |  SCENE=  }}
===Crystal structure of the C-terminal segment of FANCM in complex with FAAP24===
{{ABSTRACT_PUBMED_24003026}}


==Disease==
==Crystal structure of the C-terminal segment of FANCM in complex with FAAP24==
[[http://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.  
<StructureSection load='4m6w' size='340' side='right'caption='[[4m6w]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[4m6w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M6W FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN]] ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.<ref>PMID:16116422</ref> <ref>PMID:16116434</ref> [REFERENCE:7][REFERENCE:8] [[http://www.uniprot.org/uniprot/FAP24_HUMAN FAP24_HUMAN]] Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m6w OCA], [https://pdbe.org/4m6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m6w RCSB], [https://www.ebi.ac.uk/pdbsum/4m6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m6w ProSAT]</span></td></tr>
[[4m6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6W OCA].
</table>
 
== Disease ==
==Reference==
[https://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.
<ref group="xtra">PMID:024003026</ref><references group="xtra"/><references/>
== Function ==
[https://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN] ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.<ref>PMID:16116422</ref> <ref>PMID:16116434</ref> [REFERENCE:7][REFERENCE:8]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: RNA helicase]]
[[Category: Large Structures]]
[[Category: Ding, J.]]
[[Category: Ding J]]
[[Category: Tong, L.]]
[[Category: Tong L]]
[[Category: Yang, H.]]
[[Category: Yang H]]
[[Category: Zhang, T.]]
[[Category: Zhang T]]
[[Category: Dna binding protein]]
[[Category: Dna repair]]
[[Category: Faap24]]
[[Category: Fancm]]
[[Category: Fanconi anemia]]
[[Category: Xpf/mus81]]
Retrieved from "https://proteopedia.org/4m6w"